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    Chronic Sleep Disorder - DM

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    Marsella Epifania Suwignyo
    Chronic sleep disorders can lead to diabetes (DM) through several pathways. Less restorative slow-wave sleep increases ghrelin and decreases leptin, promoting obesity. Oxidative stress and impaired glucose tolerance then cause insulin resistance, beta-cell dysfunction, and poor glycemic control, resulting in DM.

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    Chronic Sleep Disorder - DM

    Uploaded by

    Marsella Epifania Suwignyo
    7 views2 pages
    Chronic sleep disorders can lead to diabetes (DM) through several pathways. Less restorative slow-wave sleep increases ghrelin and decreases leptin, promoting obesity. Oxidative stress and impaired glucose tolerance then cause insulin resistance, beta-cell dysfunction, and poor glycemic control, resulting in DM.

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    135009_Chronic sleep disorder - DM

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    Chronic sleep disorders can lead to diabetes (DM) through several pathways. Less restorative slow-wave sleep increases ghrelin and decreases leptin, promoting obesity. Oxidative stress and impaired glucose tolerance then cause insulin resistance, beta-cell dysfunction, and poor glycemic control, resulting in DM.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    Download as pptx, pdf, or txt
    7 views2 pages

    Chronic Sleep Disorder - DM

    Uploaded by

    Marsella Epifania Suwignyo
    Chronic sleep disorders can lead to diabetes (DM) through several pathways. Less restorative slow-wave sleep increases ghrelin and decreases leptin, promoting obesity. Oxidative stress and impaired glucose tolerance then cause insulin resistance, beta-cell dysfunction, and poor glycemic control, resulting in DM.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    Download as pptx, pdf, or txt
    of 2

    Chronic sleep disorder ->

    DM
    Chronic Sleep
    Disorders

    Sleep
    deprivation

    Less restorative
    slow-wave sleep
    ↑ Ghrelin ↓ Leptin

    Oxidative stress

    Insulin β-cell Impaired glucose Poor glycemic


    Obesity
    resistance dysfunction tolerance control

    1. Yoda K, Inaba M, Hamamoto K, Yoda M, Tsuda A, Mori K, Imanishi Y, Emoto M,


    Yamada S. Association between poor glycemic control, impaired sleep quality, and
    increased arterial thickening in type 2 diabetic patients. PLoS One. 2015 Apr
    14;10(4):e0122521.
    2. Rains JL, Jain SK. Oxidative stress, insulin signaling, and diabetes. Free Radic Biol
    DIABETES Med. 2011 Mar 1;50(5):567-75.
    3. Reutrakul S, Hood MM, Crowley SJ, Morgan MK, Teodori M, Knutson KL, Van
    Cauter E. Chronotype is independently associated with glycemic control in type 2
    diabetes. Diabetes Care. 2013 Sep;36(9):2523-9. 

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