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Bioprocess Reactor Design 31S3206: Pendahuluan
Bioprocess Reactor Design 31S3206: Pendahuluan
31S3206
PENDAHULUAN
02/10/2021
Intended Objectives
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Grading
15% 20%
15% Homework
Mid Exam
Final Exam
25% Quizzes
25%
Mini Project
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Rules
Punctual (10 min. tolerance)
Be dressed in compliance with ITDel
standards
Refrain from making unnecessary noises
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BASIC CONCEPTS
02/10/2021
Reactor
A place where a/some reaction undergo(es)
Anything in the universe can function as reactors:
◦ Sun
◦ Beaker glass
◦ Stainless-steel tanks
◦ Glass tubes
◦ Solar cell
◦ Organism cell
◦ etc.
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Reactor
Reactors can be operated in several modes:
◦ Batch feed is introduced one time and subjected to reaction, product
is collected after reaction finishes
◦ Continuous feed and product stream are introduced and collected
continuously
◦ Semi-batch/semi-continuous certain amount of feed is introduced
at the beginning of reaction, afterwards, remaining feed is introduced
continuously until the end of reaction; product is collected afterwards
In all three systems, mass and energy balance systems
become different
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In reactor design problems, any engineer has to be able to
use two primary tools:
◦ Conservation Equations
◦ Constitutive Equations
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Conservation Constitutive
Equation Equation
• Mass • Various
• Energy Examples: ideal
• Momentum gas eq., Fourier
conduction,
reaction rate
kinetics
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#menolakforget
Mass Balance
𝑖𝑛𝑝𝑢𝑡 +𝑟𝑒𝑎𝑐𝑡𝑖𝑜𝑛=𝑜𝑢𝑡𝑝𝑢𝑡
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Energy Balance
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Reactor vs. Bioreactor
In bioreactor, reactions involved are biochemical (biological)
reactions
◦ Fundamental levels: enzymatic conversion, phosporilation, etc.
◦ More complex level: metabolic pathway
◦ Integrated system: cellular activity
Bioreactors have much more complex reactions than most
chemical reactors
◦ In bioreactors, it is more convenient to use generalised/simplified
approach rather than step-wise kinetic approach
Details more on this course
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Why Bioreactors?
Future trends show inclination to cleaner processes to replace
conventional chemical reactions:
◦ Electrical reactions (electrochemistry)
◦ Solar-powered reactions
◦ Biomass-based systems
◦ Biological systems
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Required Prior Knowledges
Mass and energy balance
Transport phenomena
Enzymatic reaction kinetics and catalysis
Microbial metabolism
Microbial systems in industries
Mathematical means
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REFERENCES