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Chapter 3 Antigens
Chapter 3 Antigens
• Determined by 4 properties:
• Degree of Foreignness
• Molecular size
• Chemical structure + heterogeneity
• Ability to be processed and presented by an
APC
1) Degree of Foreignness
• The body must be able to distinguish “self” from “non-
self”
• the greater the phylogenetic distance between 2
organisms, the greater the structural differences, hence
foreignness (Ex: BSA ->rabbits; chicks vs goats)
• Some macromolecules show conservancy of structure
across phyla (e.g., collagen and cytochrome C)
• Other macromolecules “outside” an organism’s system
can be immunogenic! (e.g., cornea and sperm cells)
2) Molecular size
• Most immunogens are 100,000 daltons (Da)
• Most molecules < 5-10,000 are poor ones
3) Chemical structure/heterogeneity
• All 4 levels of protein structure contrib to
structural complexity…1°, 2°, 3°, 4°
• Lipids can induce IR if presented properly
– Lipids are typically ‘haptens’ carried by proteins (Ab’s
are produced vs the lipid portion)
B cell response