ERYTHROPOIESIS

Tujuan Pembelajaran 1
 Sumsum Tulang
• Hematopoiesis –
eritropoiesis.
• Pada seseorang usia lanjut,
hematopoiesis terjadi di
verterbrae, ribs, dan
sternum.

Sumber:
http://library.open.oregonstate.edu/aandp/wp-
content/uploads/sites/9/2017/09/marrow_skel
e-1024x920.png
Formasi Sumsum Tulang

Sumber:
Bunn and Aster, Pathophysiology of Blood
Disorders. 2011
Histologi Normal Sumsum Tulang

Sumber:
Robbin and Cotran, Atlas of Pathology. 2015
 Komponen Selular Eritropoiesis
1. Progenitor cells
• CFU-GEMM, BFU-E, CFU-E, normoblast
2. Precursor cells
• Pronormoblas  basofilik normoblast 
polychromatophilic normoblasts  orthochromic
normoblasts  orthochromic erythroblast 
retikulosit.
3. Erythroblasts nucleation
Sumber:
Hoffman, Hematology: Basic Principles and
Practice, 2017.
Regulasi Pembentukan Eritrosit

Sumber:
Marks, Basic Medical Biochemistry. 2015
Eryhthropoetin Receptors

Sumber:
Kaushansky, William Hematology. 2016.
 Skema Pembentukan Eritrosit

Sumber:
Tortora, Principles of Anatomy and Physiology,
2012.
Skema Pembentukan Eritrosit

Sumber:
Hoffman, Hematology: Basic Principles and
Practice, 2017.
 DAFTAR PUSTAKA
1. Robbin and Cotran. Red Blood Cell Disorders. Atlas of Pathology 3rd
edition, ELSEVIER. Philadelphia, 2015; 94
2. Gerard J Tortora. Formation of Blood Cells. Principles of Anatomy and
Physiology 13th edition, John Wiley & Sons, Inc. United States of
America, 2012; 733.
3. Lieberman, Marks, Marks. Tissue Metabolism. Basic Medical
Biochemistry 4th edition, Lippincott Williams and Wilkins. Baltimore,
2013; 838.
4. Kaushansky, Lichtman. The Erythrocyte. Williams Hematology 9th
edition, Mc Graw Hill. New York, 2016; 479 – 485.
5. Hoffman. Approach to Anemia in The Adult and Child. Hematology:
Basic Principles and Practice 7th edition, ELSEVIER. Philadelphia, 2017;
419.