KREBS CYCLE

GROUP 3
∙Alfurqan Maradjabessy ∙Andi Muhammad Kelvin Irvandi ∙Azizah Al Fira Hartono
∙Farel Abukarim ∙Hapsari Ardha Garini ∙Mutmainnah Dj Mandar
∙Nazla Fajriyah albaar ∙Nur Widya Tiala ∙Puji Rahayu Jamuru
∙Rizqah Zil Fadhilah ∙Sonia Buyung ∙Uways Al-Qarni Bayan

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 DEFINITION
• The krebs cycle is the final common pathway for the aerobic oxidation of
carbohydrate,lipid, and protein because glucose, fatty acids, and most amino
acids are metabolized to acetyl-CoA or intermediates of the cycle.

Why is it called the krebs cycle?

The reason why it is called the krebs cycle is as a form
of appreciation to Hans Krebs, a scientist from Germany
who is the inventor of this krebs cycle.

• The krebs cycle occurs in the mitochondrial matrix and briefly consists of 8 stages
 Asetil CoA
CoA
Koenzim
A(CoA) Sitrat Sintase

>
> Sitrat
Oksaloasetat C
> H2O
Malat
NAD+ Aconitase
dehidrogen
ase NADH

>
Isositrat
Malat
NAD+
>

NADH Isositrat
Fumarase H2O
dehidrogenase
CO2

>
Fumarat Alfaketoglutarat
>

FAD CO2
Suksinat Koenzim A (CoA)
FADH2 Alfaketoglutarat
dehidrogenase NAD+
dehidrogenase
> NADH
Koenzim A
Suksinat > (CoA) Suksinil CoA
Pi Suksinil CoA
ATP GTP GDP Sintase
ADP
THE RESULT OF KREBS CYCLE
4 CO2 (2 ATP)

6 NADH (18 ATP)

2 FADH2 (4 ATP)
 REFERENCE

Murray, R. K., Granner, D. K., & Rodwell, V. W. Harper Illustrated Biochemistry

(30th ed). The McGraw Hill-Education.

Murray, R. K., Granner, D. K., & Rodwell, V. W. Biokimia harper (Edisi 31 )

Jakarta: Buku Kedokteran EGC; 2020