FORMULATION DEVELOPMENT &

CHARACTERIZATION OF NANOPARTICLES WITH

SOME ANTIDIABETIC DRUGS

Presented by: Mr. NIMASE PRADEEP KISAN

Research guide: PROF. DR. G. VIDYASAGAR

Veerayatan Institute Of Pharmacy, Kutch- Gujarat

INTRODUCTION:

 Controlled drug delivery technology.

 Macromolecules as carriers for the drugs.
 Nanoparticles and microparticles.
 Nanoparticles: submicron (< 1µm) colloidal
particles.
 Improvement of drug bioavailability and
reduction of the dosing frequency, and may
resolve the problem of non adherence to
prescribed therapy.
 Polymers, i.e. natural, synthetic or solid
lipids and should be biocompatible and
biodegradable.
 The drug loaded in nanoparticles is
usually released from the matrix by
diffusion, swelling, erosion, or
degradation.
 Technological advantages of nanoparticles as
drug carriers:
High stability
High carrier capacity
Feasibility of incorporation of both
hydrophilic and hydrophobic
substances
Feasibility of variable routes of
administration
LITERATURE REVIEW:

 Some sustained release nanoparticles identified,

which are going to hit the market in near future.
PRODUCT DRUG Technology By

Rapamune Sirolimus Elan/Wyeth

Emend Aprepitatnt Elan/Merck

Tricor Fenofibrate Elan/Abbot

SkyePharma/First Horizon
Triglide Fenofibrate
Pharmaceuticals
 Some of the products, which are under clinical
trial for various applications:
Product Application company
Non-small cell lung
Genexol PM Samyang
cancer
Estrasorb Estrogen therapy Novavax

Medicelle Cancer treatment NanoCarrier

Flucide Anti-influenza NanoViricides

 Sustained release nanoparticles against diabetes
 Major lifestyle disease in India.
 Contributing factors: sedentary lifestyles, high
stress levels, improper sleep and deteriorating
eating habits etc.
 According to the International Diabetes
Federation report of 2006, there are around 41
million diabetics in India, which is expected to
rise to 70 million by the year 2025.
PLAN OF WORK:

 Procurement and characterization of bulk drugs.

 Procurement and characterization of polymers.
 Preparation and evaluation of critical steps
during formulation by choosing one among the
various methods (i.e. Emulsification
polymerization, spray drying, supercritical fluid
technology, electro spray method) by utilizing
various equipments for formulation (i.e.
Homogenizer, ultra sonicator, mills, spray milling,
supercritical fluid technology, electro spray,
ultracentrifugation, nanofiltration.)
PLAN OF WORK……..

 In-vitro characterization of the formulation by

taking various instruments. (i.e. particle size
analyzer, zeta potential analyzer, scanning
electron microscopy, transmission electron
microscopy)
 Stability study of some selected formulation as
per ICH guidelines.
 In-vivo characterization of the drug would be
tried against diabetes induced laboratory
animals by following standard screening
procedure.
FLOW CHART FOR METHOD OF PREPARATION & EVALUATION OF
NANOPARTICLES

NANOPARTICLES

IN-VIVO SCREENING FOR

ANTIDIABETIC ACTIVITY
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