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    CH 8 PPT Bone Part 2 - Bone Development

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    Niki Nour
    There are two mechanisms of bone development: intramembranous ossification where osteoblasts directly differentiate from embryonic tissue to form flat bones like the skull, and endochondral ossification where hyaline cartilage forms the early skeletal framework which is then replaced by osteoblasts to form most other bones like in the limbs. During endochondral ossification, small cartilage models of adult bones are formed which are then replaced by bone through the actions of osteoblasts and osteoclasts.

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    CH 8 PPT Bone Part 2 - Bone Development

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    Niki Nour
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    There are two mechanisms of bone development: intramembranous ossification where osteoblasts directly differentiate from embryonic tissue to form flat bones like the skull, and endochondral ossification where hyaline cartilage forms the early skeletal framework which is then replaced by osteoblasts to form most other bones like in the limbs. During endochondral ossification, small cartilage models of adult bones are formed which are then replaced by bone through the actions of osteoblasts and osteoclasts.

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    Ch 8 PPT Bone part 2- bone development

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    There are two mechanisms of bone development: intramembranous ossification where osteoblasts directly differentiate from embryonic tissue to form flat bones like the skull, and endochondral ossification where hyaline cartilage forms the early skeletal framework which is then replaced by osteoblasts to form most other bones like in the limbs. During endochondral ossification, small cartilage models of adult bones are formed which are then replaced by bone through the actions of osteoblasts and osteoclasts.

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    16 views11 pages

    CH 8 PPT Bone Part 2 - Bone Development

    Uploaded by

    Niki Nour
    There are two mechanisms of bone development: intramembranous ossification where osteoblasts directly differentiate from embryonic tissue to form flat bones like the skull, and endochondral ossification where hyaline cartilage forms the early skeletal framework which is then replaced by osteoblasts to form most other bones like in the limbs. During endochondral ossification, small cartilage models of adult bones are formed which are then replaced by bone through the actions of osteoblasts and osteoclasts.

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    of 11

    Chapter 8 part 2:

    Bone Development
    Osteogenesis
    •2 mechanisms
    • Intramembranous ossification
    • Osteoblasts differentiate directly
    from embryonic tissue
    • Endochondral ossification
    • Hyaline cartilage forms early
    skeletal framework
    • As development proceeds, cartilage
    is eroded and replaced by
    osteoblasts
    Intramembranous
    Ossification
    • Begins within membranes in
    embryonic tissues
    • Skull, mandibles, scapula, clavicle
    • Embryonic tissue condenses,
    differentiates into osteoblasts
    • Osteoid (early bone fibers) secreted,
    calcifies into bone
    • Groups of osteoblasts and bone grow,
    fusing with one another and maturing
    into compact and cancellous bone
    Intramembranous
    Ossification
    Osteoclasts
    • Motile
    • Multi-nucleated, large
    • Similar to macrophages
    (derived from
    monocytes in marrow)
    • Mostly found in
    cancellous bone
    Endochondral
    Ossification
    • Small “models” of adult
    bones are formed of
    cartilage
    • Endochondral ossification
    is the method of
    osteogenesis for most
    bones in the body
    • Easiest to see in long bones
    Endochondral
    Ossification
    Endochondral
    Ossification
    Endochondral
    Ossification

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