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Roller Compaction Granulation Technology
Roller Compaction Granulation Technology
GRANULATION BY ROLLER
COMPACTION
GROUP MEMBERS:
GULNAZ BADAR
NAYAB LIAQAT
ANEES ANJUM
YUSRA JAVID
Contents
Introduction
Formulation design
Equipment design
Roller compaction theory
Design of roller compaction
Process variables
conclusions
Introduction Principle Theory Equipment Process Merits & Applications
Working
variable Demerits
Loose powder
Feeder Design
Roll Surface
Gravity Feeder
Smooth
Forced Feeder Crumpled
Fluted
Crusher
Regions
Orientation Screening
Slip
Horizontal Nip
Vertical Extrusion
In-cline
Introduction Principle Theory Equipment Process Merits & Applications
Working
variable Demerits
Feed
01
02 Compression
Flake Crushing
03
04 Screening
Introduction Principle Theory Equipment Process Merits & Applications
Working
variable Demerits
Roller gap
Introduction Principle Theory Equipment Process Merits & Applications
Working
variable Demerits
Merits Demerits
Major advantage of dry granulation over wet granulation A major disadvantage of roller compaction is the
is the absence of water or any other organic solvents. production of non-compacted powders.
Suitable for those drugs which are moisture or heat Because no liquid binder is used
sensitive.
Suitable for the compounds which have a low melting Less product yields obtained as compared to the wet
point or degrade rapidly on heating. granulation process.