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Bio 11 20102011 Human Circulation and Gas Exchange
Bio 11 20102011 Human Circulation and Gas Exchange
Bio 11 20102011 Human Circulation and Gas Exchange
RNS Science
Organismal
level
Circulatory system
Cellular level
Energy-rich
molecules Cellular respiration ATP
from food
Capillaries of
Anterior
head and
vena cava
forelimbs
Pulmonary
Aorta Pulmonary
9 artery
artery
6
Capillaries
of right lung Capillaries
2 of left lung
3 4
3
11
Pulmonary
vein Pulmonary
5 Left atrium vein
1
Right atrium 10
Left ventricle
Right ventricle Aorta
Posterior
vena cava Capillaries of
abdominal organs
8 and hind limbs
Figure 42.5
Copyright © 2005 Pearson Education, Inc. publishing as Benjamin Cummings
The Mammalian Heart: A Closer Look
– http://www.nhlbi.nih.gov/health/dci/Diseases/hhw/hhw_pum
Pulmonary
Anterior vena cava artery
Pulmonary Pulmonary
veins veins
Semilunar Semilunar
valve valve
Atrioventricular
Atrioventricular valve
valve
Posterior
vena cava Right ventricle
Figure 42.6 Left ventricle
0.1 sec
Semilunar
valves
0.3 sec open
0.4 sec
AV valves
open
AV valves
1 Atrial and closed
ventricular
diastole 3 Ventricular systole;
atrial diastole
Figure 42.7
Copyright © 2005 Pearson Education, Inc. publishing as Benjamin Cummings
• The heart rate, also called the pulse
– Is the number of beats per minute
AV node Bundle
SA node branches
(pacemaker)
Heart Purkinje
apex fibers
ECG
Figure 42.8
Basement
membrane
Endothelium 100 µm
Valve
Endothelium Endothelium
Smooth Smooth
muscle muscle
Capillary
Connective
Connective
tissue
tissue
Artery Vein
Venule
Figure 42.9 Arteriole
Skeletal muscle
Valve (closed)
Figure 42.10
• Diastolic pressure
– Is the pressure in the arteries during diastole
Blood pressure
reading: 120/70
Sounds
Sounds stop
audible in
stethoscope
Artery
Artery
closed
2 A sphygmomanometer, an inflatable cuff attached to a 3 A stethoscope is used to listen for sounds of blood flow
pressure gauge, measures blood pressure in an artery. below the cuff. If the artery is closed, there is no pulse
The cuff is wrapped around the upper arm and inflated below the cuff. The cuff is gradually deflated until blood
until the pressure closes the artery, so that no blood begins to flow into the forearm, and sounds from blood
flows past the cuff. When this occurs, the pressure pulsing into the artery below the cuff can be heard with
exerted by the cuff exceeds the pressure in the artery. the stethoscope. This occurs when the blood pressure
is greater than the pressure exerted by the cuff. The
pressure at this point is the systolic pressure.
Figure 42.12
Copyright © 2005 Pearson Education, Inc. publishing as Benjamin Cummings
• Blood pressure is determined partly by cardiac
output
– And partly by peripheral resistance due to
variable constriction of the arterioles
• In one mechanism
– Contraction of the smooth muscle layer in the
wall of an arteriole constricts the vessel
Immunoglobulins Defense
(antibodies)
Erythrocytes
(red blood cells) 5–6 million Transport oxygen
and help transport
carbon dioxide
Separated
blood
elements Leukocytes 5,000–10,000 Defense and
(white blood cells) immunity
Basophil Lymphocyte
Eosinophil
Neutrophil
Monocyte
Platelets 250,000 Blood clotting
400,000
Figure 42.15
• Transport by Blood
What is transported What it is or does
Nutrients Glucose, amino acids, etc
Organismal
level
Circulatory system
Cellular level
Energy-rich
molecules Cellular respiration ATP
from food
50 µm
Esophagus
Trachea
Right lung
50 µm
Bronchus
Bronchiole
Diaphragm
Heart SEM Colorized SEM
Figure 42.23
Copyright © 2005 Pearson Education, Inc. publishing as Benjamin Cummings
• Describe the features of alveoli that adapt them
to gas exchange.
– This should include a large total surface area,
120 27
160 0.2 Alveolar spaces
O2 CO2 O2 CO2
Alveolar 104 40
O2 CO2
epithelial
cells
CO2 O2 2
Blood Blood
1 leaving
entering
alveolar O2 alveolar
2
CO
capillaries capillaries
Alveolar
40 45 104 40
O2 CO2 capillaries O2 CO2
of lung
Pulmonary Pulmonary
arteries veins
Systemic
Systemic arteries
veins Heart
Tissue
O2
CO2 capillaries
3
Blood 4 Blood
leaving entering
tissue tissue
capillaries capillaries
40 45 CO2 O2 100 40
O2 CO2 O2 CO2
Tissue
cells
Figure 42.27 <40 >45
O2 CO2