BENCH TO BEDSIDE

TRANSLATING BASIC SCIENCE TO CLINICAL PRACTICE

Fadhlan Ardhuha, MD

Apoptosis and Organ Dysfunction in Sepsis

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It is estimated that more than 30 million people globally are diagnosed with sepsis each
year, leading to 5 million deaths
Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P, et al. Assessment of Global
Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations. Am J Respir Crit Care Med.
2016;193(3):259-72.

Sepsis:
Suspected or documented infection and acute organ dysfunction
(defined as an increase of ≥ 2 points in SOFA points)

Septic shock:
Sepsis and vasopressor therapy needed to elevate MAP ≥65
mmHg and lactate >2 mmol/L despite adequate fluid
resuscitation.

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Inflammation Imbalance

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Mitochondrial Damage

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Vascular Dysfunction

Systemic arterial and venous vasodilation Capillary permeability is increased

excessive production of nitric oxide (NO) expression of Ang-2

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Michiels C. Endothelial cell functions. J Cell Physiol.
2003;196(3):430-443. 10
Vascular Dysfunction: the Failure of the Circuit

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Thank You

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Tambahan

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Davie, EW, Kulman, JD. An overview of the structure and function of thrombin. Semin Thromb
Haemost. 2006;32(suppl 1):3-15.
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Hypothesis of the origin of Covid-19-
associated pulmonary emboli and lung
microcirculatory thrombotic disease:
Interaction of inflammation and
coagulation.
Laura C Price et al. Eur Respir J
doi:10.1183/13993003.01608-2020

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