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Genetika Dan Embriologi Umum
Genetika Dan Embriologi Umum
Genetika Dan Embriologi Umum
UMUM
dr. Anung Putri Illahika.,M.Si
Laboratorium Anatomi
Fakultas Kedokteran
Universitas Muhammadiyah Malang
• Awalnya
manusia Haploid gametes (n = 23)
mempunyai
46 kromosom Egg cell haploid
(diploid)
Sperm cell haploid
• Proses MEIOSIS FERTILIZATION
Meiosis akan
mengurangi
jumlah sel Diploid
menjadi 23 zygote
(2n = 46)
kromosom Multicellular
diploid adults
(haploid) (2n = 46)
• Penyatuan ovum
Mitosis and
+ sperma akan development
menghasilkan
46 kromosom
GAMETOGENESIS
PEMBENTUKAN SEL
SEKS PRIA DAN
WANITA ATAU
SEL GAMET YANG
BERASAL DARI
GERM CELLS
OOGENESIS
TERJADI PADA
WANITA
SPERMATOGENESIS
TERJADI PADA PRIA
Testis and Formation of Sperm
2n
2n
n
The Ovary and Formation of an
Ovum
2n
GAMETOGENESIS
• MITOSIS: MENJADI 2 SEL YANG SAMA
• MEIOSIS :
– I : - PAIRING KROMOSOM HOMOLOG
- CROSS OVER (PERTUKARAN SEGMEN)
– II: - SINTESIS DNA TIDAK TERJADI
- PEMISAHAN KROMOSOM GANDA
MENJADI TUNGGAL
MITOSIS
• Mitosis is a continuum
but biologists distinguish
4 stages
– Prophase
– Metaphase
– Anaphase
– Telophase
MEIOSIS
Centrosomes Microtubules
Sites of crossing over Metaphase Sister chromatids
(with attached to
plate remain attached
centriole Spindle kinetochore
pairs)
TELOPHASE I TELOPHASE II
PROPHASE II METAPHASE II ANAPHASE II
AND CYTOKINESIS AND CYTOKINESIS
Cleavage
furrow
Sister Haploid
chromatids daughter cells
separate forming
normal
disjoining non-
disjoining
A : Belum Kapasitasi
B : Kapasitasi
C : Reaksi Akrosom
A B
FERTILISASI
Embryonic Fetal
development development
Postnatal Development
Development Overview
Eggs form and mature in female
reproductive organs, and sperm Gamete formation
form and mature in male frog egg
reproductive organs.
Zygote
Blastocyst
with blastocoele cavity
Periode implantasi
Berlangsung mulai hari ke 6 saat
melekatnya blastocyst pada epithel
endometrium sampai hari ke 12 setelah
ovulasi
Terdiri dari :
Cytotrophoblast
Syncytiotrophoblast
paired
neural folds
pharyngeal
arches
somites
KELAINAN
Teratoma sacrococcygeal (sisa primitive streak
Neural tube defect (meningocele dll)
PERIODE FETAL
►4th week = organogenesis
►Critical time in development
►Embryo ~ 5 mm
Second Month
Embryo ~ 25 mm
Great changes occur in
morphology
Limbs assume adult shape
Major internal organs
evident
Fetal
• Development
Three Months
• Development is essentially
complete (except for lungs &
brain)
From 3 months on the developing
Second trimester
Fetus ~ 30 cm long (1 foot, by
end of 6th month) ~ 4 months
A time of growth!
Bone formation
Hair growth
Fetal Development
• Third trimester
• Weight ~ doubles
Major change is
great increase in
size
Most major nerve
tracts formed in brain
Nutrients from
mother’s blood via
placenta
Placenta
Placental-Fetal circulation
Sesungguhnya kami (Allah) menciptakan manusia
dalam bentuk yang sebaik-baiknya
QS 95:4
TWIN
Normal Female: 46,XX
Normal Male: 46,XY
Autosomal Abnormalities
Trisomy 21
Down Syndrome 47,XY,+21
General features:
Some growth retardation (GR)
Reproductive anomalies/problems
Good viability
Prenatally diagnosable
Associated with spontaneous abortion (Sab)
Sex Chromosome Anomalies
• small testes
• aspermia
• long limbs
• retardation in some
• fertility in some