SUBMITTED BY: AMTUL NASEER

SUBMITTED TO: PROF. ABU BAKKAR

SUBJECT: PRE FORMULATION AND PRODUCT
DEVELOPMENT
DEGREE: MPHIL PHARMACEUTICS
EUTECTIC MIXTURE VS CO CRYSTAL

Title Lorem Ipsum

 DEFINITION EUTECTIC MIXTURE/CO-CRYSTALS
EUTECTUC MIXTURE
• Mixture of two or more components which usually do
not interact to form chemical compound, but which at
certain ratios inhibit the crystallization, process of one
another resulting in system having a lower melting
point than either of the components.
• The eutectic temperature is the lowest possible melting
temperature for all of the mixing ratios of the
component substances in a eutectoid. At this
temperature, the super-lattice will release all of its
components and the eutectic system will melt into a
liquid as a whole
CO CRYSTALS
• Cocrystals are "solids that are crystalline single phase
materials composed of two or more different molecular
or ionic compounds generally in a stoichiometric ratio
which are neither solvates nor simple salts/consist of
two or more components that form a unique crystalline
structure having unique properties." Several
subclassifications of cocrystals exist.
 EXAMPLES

Example Example
Eutectic mixture Co-crystals
Sodium chloride and water form a eutectoid when the Fluoxetine
mixture is 23.3% salt by mass with a eutectic point at
-21.2 degrees Celsius. The system is used to 
make ice cream and to melt ice and snow.

Local anesthesia Carbamazepine

Ibuprofen, Thymol
DIAGRAMATIC REPRESENATATION

Eutectic mixture Co-crystal

PROPERTIES
Eutectic mixture
• Melts below the melting point of
individual components.
• Components are miscible in liquid state
but immiscible in solid state.
• Melting point is always fixed.
Co-crystals
• The components interact via non-covalent
interactions such as hydrogen bonding, 
ionic interactions, 
van der Waals interactions and Π-
interactions. 
• These interactions lead to a cocrystal
lattice energy that is generally more stable
than the crystal structures of the individual
components.
PROPERTIES

•  The intermolecular interactions and

resulting crystal structures can generate
physical and chemical properties that
differ from the properties of the individual
components.
SIMILARITY

 Non covalent derivatives

 Made up of two or more components but at end are homogenous.
 Both lack long range order.
 DIFFERENCE
Co-crystal
• Enthalpy advantage outweighs Entropy loss.
• Necessarily crystalline.
• Primary supramolecular growth units should be at least
3 molecules long for co-crystal to form.
• Non covalent derivative with crystal packing shape
compatibility found.
• Contains two eutectic points and region of co crystal at
the maximum between the two eutectic points. This
results in a typical W-shaped phase diagram.
Eutectic Mixture
Entropy gains outweighs Enthalpy loss.
Not necessary.
Primary supramolecular growth unit is restricted to finite
heterodimer.
Non covalent derivative but without packing shape
compatibility.
Thermal data for eutectic mixtures results in a classic V
shape where the minimum point of the V represents the
molar ratio and temperature at the eutectic point
THANK YOU