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PERBEDAAN PENYAKIT MENULAR DAN

PENYAKIT TIDAK MENULAR


PENYAKIT MENULAR NCDs

Single necessary agent No single necssary agent


Specific agent disease relationship One-on-one correspondence between agent
and disease very rare
Causes are relatively well understood Causes unknown, interventions usually
basewd on risk factors
Short incubation period Long latency period
Single exposure usually sufficient May require multiple exposures to same or
multiple agents
Usually produce acute disease Most often produce chronic disease (Tp ada
yg akut, mis keracunan, KLL)
Acquired immunity possible Acquired immunity unlikely
Dx based on tests specific for disease agents Dx often dependent on nonspecific
symptoms
KELOMPOK BESAR
PENYAKIT
1. Kongenital
2. Infeksi
3. Trauma
4. metabolik
5. Imunologis
6. degeneratif
7. Neoplasma
8. psikis
NEW EMERGING AND
REEMERGING INFECTIOUS
DISEASES

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Definition

•NewEmerging infectious diseases


1.newly identified or
2.previously unknown infections
3.knowing but appearing in new geographic area
4.Increase abruptly

•Re-emerging infectious diseases


re-appearance of, or
increase in number of,
infections from a disease previously known

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Leading Global Causes of Death -
1990
The Ten Leading Causes of Death, 1990
Developed Developing
1 Ischemic heart disease Lower Respiratory Infections
2 Cerebrovascular disease Ischemic heart disease
3 Lung cancer Cerebrovascular disease
4 Lower respiratory infections Diarrheal disease
5 COPD Perinatal conditions
6 Colon cancer Tuberculosis
7 Stomach cancer COPD
8 Road traffic accidents Measles
9 Self-inflicted injuries Malaria
10 Diabetes mellitus Road traffic accidents
Infectious Diseases: A World in Transition

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•The human species continues to
change and to change its surroundings:
the ways we live, work, relax;
the places we go;
the foods we eat ...

•The changing nature of


our interactions with each other and
with our environment alters
the dynamics of disease epidemiology and
exposes us to new threats.

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ENVIRONTMENT

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EMERGING DISEASES ARE NOT NEW TO MANKIND

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NEWLY IDENTIFIED PHATOGENS
(1973- 1989)

1973 Rotavirus
1975 Parvovirus B19
1976 Cryptosporidium parvum
1977 Ebola virus, Legionella pneumophilia,
Hantaan virus, Campylobacter jejuni
1980 HTLV-1
1981 Staphylococcus toxin
1982 E. coli O157, HTLV-2, Borrelia burgdoferi
1983 HIV virus, Helicobacter pylori
1988 HHV-6, Hepatitis E
1989 Ehrlichia chaffeensis, Hepatitis C
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Newly identified pathogens (1990 - 1999)

1990 Guanarito virus


1991 Encephalitozzon hellem
1992 Vibrio cholerae O139
1992 Bartonella henselae
1993 Sabia virus
1995 Hepatitis G virus
1995 Human herpesvirus-8
1996 TSE causing agent (nvCJD)
1997 Avian influenza (Type A H5N1)
1999 Nipah virus, Avian Influenza H9N1, Stealth viruses

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Newly identified pathogens (1997 – 2009)

•1998 Nipah encephalitis


•2003 SARS
•2004 Avian influenza H5N1
•2006 Chikungunya- re-emergence
•2009 Pandemic influenza A H1N1

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Since 1973
39 newly identified pathogens,
examples : Others re-emerged
1973 Rotavirus Dengue/DHF
1977 Ebola virus, Hantaan virus Cholera Malaria
1980 HTLV-1 Chikungunya
1983 HIV virus H pylori J. Encephalitis
1988 Hepatitis E Leptospirosis
1992 Vibrio cholerae O139 N.meningitidis
1996 Avian influenza A (H5N1)
1999 Nipah virus
2003 SARS
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 Current estimates-
1,415 microbes are infectious for human.
 Of these, 868 (61%) considered zoonotic.
 70% of newly recognized pathogens are zoonoses.

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Examples of recent emerging and re-emerging diseases

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Risk factors for emerging zoonoses:
close human animal interface in Asia

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GEOGRAPHIC DISTRIBUTION OF PROBABLE CASES

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SARS:
THE FIRST EMERGING INFECTIOUS DISEASE OF THE 21ST CENTURY

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Emergence of HPAI (H5N1)
2003-June 2008 a total of 385 cases with 243 deaths

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EMERGENCY DENGUE FEVER/DENGUE HAEMORRHAGIC FEVER

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