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  • Enteral Routes of Administration

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    Mustafa Saßer
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    This document discusses different enteral routes of drug administration including oral, sublingual, and rectal routes. It provides details on the characteristics, advantages, disadvantages, and factors affecting absorption and bioavailability for each route. Specifically, it outlines how first pass metabolism in the gut and liver can decrease bioavailability for some orally administered drugs and discusses ways to potentially overcome this, such as using sublingual or rectal administration routes instead.

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    Enteral routes of administration

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    This document discusses different enteral routes of drug administration including oral, sublingual, and rectal routes. It provides details on the characteristics, advantages, disadvantages, and factors affecting absorption and bioavailability for each route. Specifically, it outlines how first pass metabolism in the gut and liver can decrease bioavailability for some orally administered drugs and discusses ways to potentially overcome this, such as using sublingual or rectal administration routes instead.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pptx, pdf, or txt
    17 views16 pages

    Enteral Routes of Administration

    Uploaded by

    Mustafa Saßer
    This document discusses different enteral routes of drug administration including oral, sublingual, and rectal routes. It provides details on the characteristics, advantages, disadvantages, and factors affecting absorption and bioavailability for each route. Specifically, it outlines how first pass metabolism in the gut and liver can decrease bioavailability for some orally administered drugs and discusses ways to potentially overcome this, such as using sublingual or rectal administration routes instead.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pptx, pdf, or txt
    of 16

    PO311

    Lab1
    (Enteral Routes of Administration)
    Effect Of Administered Drug

    Systemic Local
    (General) (Topical)
    Routes of Administration

    Enteral Others
    Enteral Route
    1-Sublingual:

    2-Oral:
    3-Rectal:
    a- Upper rectum :
    b- Lower rectum :
    1- Oral Route:
    Characteristics:
    Advantages:

    Disadvantages:
    Factors Affecting Oral Absorption:
    3- Gastric Emptying:
    a- Metoclopramide: (Primperan, Anti-emetic)

    b- Atropine:

    4- Gut Motility:
    5- pH:
    5- pH:

    6- Presence of food & other drugs:


    7- First Pass Effect (Pre-Systemic Metabolism):
    ↓ Bioavailability
    a- Gut:

    b- Hepatic:
    -

    8- Factors related to the drug:

    ? How to OVERCOME Hepatic First Pass Metabolism?


    Enteral Route:
    1- Oral.
    2- Sublingual.
    3- Rectal.
    2-Sublingual (Pellet or Linguat)
    *Example:

    *Advantages:
    3-Rectal Route
    1- Solid (Suppository):

    2- Fluid (Enema):
    Evacuant (Cleansing) enema Retention enema
    ♣ Advantages:
    Enteral Route:
    1- Oral.
    2- Sublingual.
    3- Rectal.

    Thank You

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