RISK FACTORS

Risk factors have been identified that predispose children to COVID-19 infection fol
lowing by:
• Immunosuppression (30.5%)
• Respiratory conditions (21%)
• Cardiovascular conditions (13.7%)
• Complex congenital malformations (10.7%)
• Hematologic conditions (3.8%)
• Neurologic conditions (3.4%)
• Obesity (3.4%)
• Prematurity (3.4%)
• Endocrine/metabolic conditions (2.1%)
• Renal conditions (1.7%)
• Gastrointestinal conditions (0.5%)
RISK FACTORS
A more recent systematic review for evaluated the risk of severe
COVID-19 infection in children with pre-existing conditions :
• Children with pre-existing conditions are 1.8 times more likely to
have severe COVID-19 infection and/or require intensive care.
• Children with pre-existing conditions are 2.8 times more likely to
die compared to children without pre-existing conditions.
• Obese children are 2.9 times more likely to have severe COVID-1
9 infection.
• mechanism to explain is higher visceral adiposity induces higher
levels of local and systemic inflammatory cytokines =>>IL-6 and
CRP.