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Explain about
metaplasia
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Definition

 A reversible change in which one adult cell type (epithelial cell or

mesenchymal) is replaced by another adult cell type

 Metaplasia is the replacement of one differentiated somatic cell type

with another differentiated somatic cell type in the same tissue.
Typically, metaplasia is triggered by environmental stimuli, which may
act in concert with the deleterious effects of microorganisms and
inflammation. The cell of origin for intestinal metaplasia in the
oesophagus and stomach and for pancreatic acinar–ductal
metaplasia has been posited through genetic mouse models and
lineage tracing but has not been identified in other types of
metaplasia, such as squamous metaplasia. 

Giroux, V., & Rustgi, A. K. (2017). Metaplasia: tissue injury adaptation and a precursor to the dysplasia-
cancer sequence. Nature reviews. Cancer, 17(10), 594–604. https://doi.org/10.1038/nrc.2017.68
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Types

1. Epithelial metaplasia (adaptasi proteksi)

1. Squamous metaplasia

2. Columnar metaplasia

2. Connective tissue metaplasia

1. Myositis ossificans (manifestasi tumor)
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Metaplasia

 Organ  Squamous metaplasia in cervical uterine with

uterine prolapsed

 Morphology:

 Endocervix contains surface epithelium, gland, and

stromal component
 The surface epithelium and gland epithelium lined by
stratified squamous cells (normal: a single layer
cylindrical cells)
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