HEART FAILURE

YOS AKBAR IRMANSYAH

PEMBIMBING :

DR. IRNIZARIFKA SPJP, FIHA

 Definition
• Heart failure (HF) is a complex clinical syndrome resulting from
structural and functional impairment of ventricular filling or ejection
of blood.
• Although the clinical syndrome of HF may result from abnormalities
or disorders involving all aspects of cardiac structure and function,
most patients have impairment of myocardial function, ranging from
normal ventricular size and function to marked dilation and reduced
function.

Zipes, D.P., Libby, P., Bonow, R.O., Mann, D.L. and Tomaselli, G.F., 2018. Braunwald's Heart Disease E-Book: A Textbook of
Cardiovascular Medicine. Elsevier Health Sciences. 2
Pathophysiology of HF

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 How Heart Works

 Leonard S. Lilly. Pathophysiology Of Heart Disease : a Collaborative Project of 4

Medical Students and Faculty. Philadelphia :Lippincott Williams & Wilkins,
 Leonard S. Lilly. Pathophysiology Of Heart Disease : a
Collaborative Project of Medical Students and Faculty. 5
Philadelphia :Lippincott Williams & Wilkins, 2016
 Index event may have an abrupt onset, as in the case of a
myocardial infarction (MI); it may have a gradual or insidious
onset, as in the case of hemodynamic pressure or volume
overloading, or it may be hereditary,as in the case of many of
the genetic cardiomyopathies.

Zipes, D.P., Libby, P., Bonow, R.O., Mann, D.L. and Tomaselli, G.F., 2018. Braunwald's Heart Disease E-Book: A Textbook of
Cardiovascular Medicine. Elsevier Health Sciences. 6
Zipes, D.P., Libby, P., Bonow, R.O., Mann, D.L. and Tomaselli, G.F., 2018. Braunwald's Heart Disease E-Book: A Textbook of 7
Cardiovascular Medicine. Elsevier Health Sciences.
Langenickel, T.H. and Dole, W.P., 2012. Angiotensin receptor-neprilysin inhibition with LCZ696: a novel approach for the treatment of heart 8
failure. Drug Discovery Today: Therapeutic Strategies, 9(4), pp.e131-e139.
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Framingham Diagnostic Criteria for Heart Failure

King, M., Kingery, J.E. and Casey, B., 2012. Diagnosis and evaluation of heart failure.  American Family Physician, 85(12), pp.1161-1168. 10
 ACC/AHA Stages of HF vs NYHA
Functional Classification

Zipes, D.P., Libby, P., Bonow, R.O., Mann, D.L. and Tomaselli, G.F., 2018. Braunwald's Heart Disease E-Book: A Textbook of
Cardiovascular Medicine. Elsevier Health Sciences. 11
Ponikowski, P., et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure:. European heart journal, 37(27), pp.2129-2200. 12
Ponikowski, et al.. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. European heart journal, 37(27), pp.2129-2200. 13
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Acute Heart Failure

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Filippatos, G. and Zannad, F., 2007. An introduction to acute heart failure syndromes: definition and classification. Heart failure reviews, 12(2), pp.87-90.
Ponikowski, P., et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure:. European heart journal, 37(27), pp.2129-2200. 19
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Heart Failure reduce Ejection Fraction

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Yancy, C.W., et al.2018. 2021 ACC expert consensus decision pathway for optimization of heart failure treatment: answers to 10 pivotal issues about heart failure with reduced ejection fraction. Journal of the
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American College of Cardiology, 71(2), pp.201-230.
2021 Updated to the 2017 ACC expert consensus decision pathway for optimization of heart failure treatment: answers to 10 pivotal issues about heart failure with reduced ejection
fraction. Journal of the American College of Cardiology
THANK YOU
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