Korsakoff’s Disease

Presented by:
Bazan, Cristy May A.
Rivero, Jewel Grace A.
 Korsakoff’s Disease
 Korsakoff's syndrome is a condition that mainly affects
chronic alcoholics

 It is also called Korsakov's syndrome, Korsakoff's psychosis

or amnesio-confabulatory syndrome
.
 It is a brain or neurological disorder caused by thiamine or
Vitamin B1 deficiency.

 The syndrome is named after Sergic neuropsychiatrist who

popularized the theory
CAUSES
 Chronic Alcoholism.
 Malabsorption
 Other severe brain disturbances .
 Dietary deficiencies
 Eating disorders
 Severe malnutrition
RISK FACTOR
The major risk factors for developing korsakoff’s disease
are malnourishment and chronic alcohol misuse.
Other risk factors for korsakoff’s disease include:

 Inability to afford medical care and proper food

 kidney dialysis- which reduces vitamin B-1 absorption

 AIDS- which makes you more likely to develop

conditions that lead to vitamin B-1 deficiency
CLINICAL MANIFESTATION
 1. Anterograde amnesia or the inability to form new
memories
 2. Retrograde amnesia or the loss of memory ( can be
severe)
 3. Confabulation or the reciting of imaginary experiences
 4. Lack of insight
 5. Apathy or the absence of interest in or concern about
emotional , social or physical life.
 6. Hallucinations or seeing and hearing are not really
present.
 7. Delirium
 8. Anxiety
 9. Fear
 10. Depression
 11. Confusion
 12. Delusions and insomnia
 13. Painful extremities
TREATMENT
 1. Thiamine by injection into a vein or a muscle or by
mouth.

 2. Stopping alcohol use to prevent additional loss of

brain function and damage the nerves .

 3. Eating a well balanced and nourishing diet with

increase intake of foods containing Vitamin BI.