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Non-Steroidal Anti-Inflammatory Drugs (Nsaids) : Dr. Nishant B. Bhansali
Non-Steroidal Anti-Inflammatory Drugs (Nsaids) : Dr. Nishant B. Bhansali
Drugs (NSAIDs)
• Anti-inflammatory effect
– By this effect produce symptomatic relief
– Do not affect the progression of the disease
– Mainly decrease inflammation by decreasing PGs
biosynthesis
– Suppress signs and symptoms of inflammation
• Antiplatelet effect
– Aspirin in low doses (75-325 mg/day) irreversibly inhibits
platelet TXA2 synthesis producing antiplatelet effect
• CVS
– Prolonged use of NSAIDs cause sodium and water
retention.
– May precipitate CCF in patients with low cardiac reserve
– Decrease the effect of antihypertensive drugs
• GIT
– NSAIDs irritate the gastric mucosa and produce nausea,
vomiting and dyspepsia.
Adverse drug reactions
• GIT
– Nausea, vomiting, dyspepsia, epigastric pain, acute
gastritis, ulceration and GI bleeding
– Ulcerogenic effect is the main drawback of NSAIDs
• Hypersensitivity
– Relatively more common with aspirin
– Skin rashes, urticaria, rhinitis, bronchospasm,
angioneurotic oedema and rarely anaphylactoid reaction
• In people with G6PD deficiency causes hemolytic
anaemia
• As an analgesic
– To relieve pain due to tootache, headache, etc.
Adverse effects
• Side effects are rare, occasionally causes skin
rashes and nausea
• Causes necrosis