ANTIULCER HERBAL FORMULATIONS

A
PROJECT REPORT
SUBMITTED TO

PUNJAB TECHNICAL UNIVERSITY

JALANDHAR (INDIA)
IN PARTIAL FULFILMENT OF THE REQUIREMENTS
FOR THE DEGREE OF

BACHELOR OF PHARMACY
By
NIKHIL CHANDEL
(1339545)
UNDER THE GUIDANCE OF
MR. RAIBARINDER SINGH
ASST. PROF.
Rayat & Bahra Institute of Pharmacy
Sahauran, District Mohali, Punjab -140104, India
2017
 INTRODUCTION:
An ulcer is basically an inflamed break in the skin or the mucus membrane lining the alimentary
tract. Ulceration occurs when there is a disturbance of the normal equilibrium caused by either
enhanced aggression or diminished mucosal resistance.

 The gastric mucosa is continuously exposed to potentially injurious agents such as acid, pepsin,
bile acids, food ingredients, bacterial products (Helicobacter pylori) and drugs. These agents have
been implicated in the pathogenesis of gastric ulcer, including enhanced gastric acid and pepsin
secretion, inhibition of prostaglandin synthesis and cell proliferation growth, diminished gastric blood
flow and gastric motility.

Classification of peptic ulcer:-

Cimetidine, Ranitidine, Famotidine, Roxatidine, omeprazole, Esomeprazole, Lansoprazole,
Pantoprazole, Rabeprazole,Dexrabeprazole., Pirenzepine,Propantheline,Oxyphenonium,Misoprostol
 SIGN AND SYMPTOMS:-
Signs and symptoms of a peptic ulcer can include one or more of the following:
•Abdominal pain;
•Abdominal fullness, nausea, and copious vomiting;
•loss of appetite and weight loss;

COMPLICATION IN PEPTIC ULCER:-

•Gastrointestinal bleeding
•Gastric outlet obstruction
•Cancer is included in the differential diagnosis (elucidated by biopsy), Helicobacter pylori
as the etiological factor making it 3 to 6 times more likely to develop stomach cancer from
the ulcer.
 Spotlight on New Peptic Ulcers Treatments:-
•Barium X-ray: a thick white liquid (barium) that you drink helps the stomach and small intestine show
up on X-rays,
•Endoscopy: a thin, lighted tube is inserted through the mouth and into the stomach to look for the
presence of an ulcer,
•Endoscopic biopsy: a piece of stomach tissue is removed so it can be analyzed.

ADVERSE EFFECTS OF ALLOPHATHIC MEDICINE:

•Nausea,
•Loose stools,
•Headache ,abdominal pain,
• Constipation,
• Muscle & joint pain
 •HERBAL DRUG STUDIES FOR PEPTIC ULCER: REVIEWS 

•There are many herbs, nutrients, and plant products that have been found to play a role in protecting
or helping to heal stomach and peptic ulcers.

•There are several botanical products with potential therapeutic applications because of their high
efficacy and low toxicity. Active principles of antiulcer activity are Flavonoids, terpenoids and
tannins.

•Some herbal drugs used for treatment of peptic ulcer are:

•Asparagus racemosus (Satavari),
•Aloe vera (Aloe),
•Emblica officinalis (Amla),
•Azadirachta indica (Neem).
 OBJECTIVE

To study the useful herbal preparation for treatment of

peptic ulcer.
PRACTICAL WORK:

MARKETED HERBAL DRUGS /FORMULATIONS

FOR PEPTIC ULCER:

1. NAME OF COMPANY: DABUR

NAME OF PRODUCT : Triphala churna (500gm)

INGREDIENT OF FORMULATION:
1.Amalaki(Emblica offinalis) , it consists of dried as well as fresh fruits of emblica offinalis
.belonging to family Euphorbiaceae .Active constitutes , vitamin C, phyllemblin, tannins.
2. Harde(Terminalis chebula),it consists of dried mature fruits of terminalis chebula.belonging
to family combretaceae. Active constitute chebulic acid, chebulagic acid, gallic acid.
3. Bahera(Terminalis belerica),it consists of dried ripe fruits of terminalis belerica ,belonging
to family combretaceae. Active constitute gallic acid,chebulagic acid.
Triphala is recommend for the treatment of peptic ulcer, indigestion constipation etc. [37]
2. NAME OF COMPANY : DABUR
NAME OF PRODUCT: Trifgol
Dabur trifgol os a isabgol based natural fiber Laxative,which also contains the goodness of
triphala.
INGREDIENT OF FORMULATION:
1. Isabgol powder, it consists of dried seeds of the plants known as plantago ovata belonging
to family plantaginaceae. Active constitute pentosan, mucilage, aldobionic acid.
2. Triphala powder.
3. aExcipents nd flavours.
Trifgol recommend for the treatment of increase stool weight, peptic ulcer. [38]
 3. NAME OF COMPANY: AyushPVT.LTD.
NAME OF PRODUCT: Ayucid capsules

Baidyanath has specially formulated AYUCID Ayurvedic tablets that help to neutralize excess acidity,
preventing heart-burn and healing ulcers. AYUCID is a combination of a number of herbs that act as
refrigerants and coolants. 
INGREDINT  OF FORMULATION: 
Amla (Emblica officinalis), Mulethi (Glycerrhiza glabra), Fumaria parviflora, Mimosa pudica,

Glycerrhiza glabra: It is a coolant and a refrigerant and helps in acid peptic diseases. Mimosa Pudica:
Heals ulcers; it is a haemostatic.
 
Fumaria Parviflora: Helps in hyperacidity.

Emblica Officinalis:  Helps in acid peptic disease and is a coolant. [41]

4. NAME OF COMPANY : AYUSHPVT.LTD AMRITSAR
NAME OF PRODUCT: Bilwa
Bilwa-: Sometimes called “Bilva” or “Bael Fruit” is one of the most frequently used plants in 
Ayurveda. Bilwa help in the treatment of peptic ulcer, vomiting, stomach cramps and intestinal
worms.  Bilwa as a specific remedy for coughs and digestive disorders.
 
  Benefits
1.Improve Digestion.
2. Reduces gastric ulcer.
3.Bilwa Can control diabetes.

INGREDIENTOF FORMULTION: Standardized Extract of Bilwa (Aegel marmelos).

 
Used- 1 capsule twice a day with water or as directed by your health provider. [42]
5. NAME OF COMPANY: AYUSHPVT.LTD.NAGROTA
NAME OF PRODUCT: GI Forte

Piper longum generally referred to as Indian long pepper. Piper longum, may be a heat and
aromatic pepper-like herb that scrapes ototoxic build up from cell walls, arteries and tissues to
cut back excess weight.

   Benefits
1.Improves the digestive system.
2.Improves Abdominal tumors.
3.Improves gastric ulcers.

INGRDIENTS OF FORMULTION : Standardized Extract of Pipli (Pipper longum)

 USED-1 capsule twice a day with water or as directed by your health provider [43]
MEDICINAL PLANTS USED BY VAIDYAS :
Most of the medicinal plant species used by the local people in this part of Himalaya find their
mention in ancient literature of Ayurveda. The traditional Vaidyas are respected by the local
community and have considerable influence on health belief and practice.Vaidyas and local people
use mainly leaf, flower, bark/stem and roots of different trees, shrubs and herbs many of which
perennial herbs with slow growing rhizomes.

1. PLANT NAME: Ajuga bracteosa wall.

Family : Lamiaceae
Common name : Neel kanth
Composition: Leaf extract consumed before meals is highly beneficial incuring and
indigestion.

2. PLANT NAME : Citrus lemon

Family : Rutaceae
Common name : Nimbu
Composition: Fruit extract mixed with mentha leaf extract and salt is taken to reliene from
acidity and gastric disorder.

3. PLANT NAME : pimpinella diversifolia.

Family : apiaceae.
Common name : bazeer
Composition : leaf,root and flower paste is taken with water to relieves from gastric disorder.
[44]
 Results
As per the discussion with the local doctor ,it was observed that the herbal formulation prescribed
for peptic ulcer.

Name of Age SEX DIAGNOSIS \TEST TREATMENT DURATION NAME OF

patients DOCTOR

Dawinder 54 F Peptic ulcer by Sukhumara Ghrita 3-4 months Dr. Shefali

Kaur Barium X-ray sharma

Sunil Kumar 40 M Peptic ulcer by Amalpitanthak loh. 2-5 months Dr. Rajbeer
Endoscopy Leela Ras singh

Sarthak 35 M Peptic ulcer by Chanderkala Ras 6-7 Dr. Ayush Jatta

Endoscopic biopsy Months

Sunil 45 M Peptic ulcer by Thyme 5 months Dr.vardhan

Barium x-ray, Extract,liquorice Aggarwal
Endoscopy extract.

Shamita 35 F Peptic ulcer by Amalpitanthak loh. 4 months Dr. Vipul Singh

Singh Endoscopy Leela Ras
Shelja 34 F Peptic ulcer by Blood Snehapanam 1-2 months Dr. Hariram
test, stool test,breath (medicated ghee) Kumar
test
Sagar Sharma 52 M Peptic ulcer by Avipatrika churna 2-3 months Dr.Aggarwal
Endoscopy,stool test and amlapitanthak
Sangeeta Singh 43 F Peptic ulcer by EGD Ayucid capsule 6-8months Dr. shubhash
(amla,mulethi) kaushal
Ronit kapoor 29 M Peptic ulcer by EGD Avipatrika churna 5 Months Dr. Keshav
and amlapitanthak Aggarwal
Sumit Kumar 36 M Peptic ulcer by Ayucid capsule 2-3 months Dr. Vipul Singh
Endoscopy,stool test (amla,mulethi)
Ayesha 41 F Peptic ulcer by Barium Sukhumara Ghrita 7Months Dr. Ayush Jatta
X-ray
Yamini garg 33 F Peptic ulcer by EGD Chanderkala Ras 5 Months Dr. shubhash
kaushal
Shrista kapoor 28 F Peptic ulcer by Barium Sukhumara Ghrita 2-3Month Dr. Ayush Jatta
X-ray
Vinkle Kapoor 45 M Peptic ulcer by EGD Chanderkala Ras 5 Months Dr. shubhash
kaushal
Daanish 34 M Peptic ulcer by Barium Avipatrika churna 8 months Dr. Vipin Kumar
X-ray and amlapitanthak
 DISCUSSION
•The finding of the study revealed that the herbal formulation used in treatment of peptic ulcer
are equally effective, has lesser side effect and economic.

•Antiulcer medications that are prescribed by the physicians to the patients are shown to
evidence decrease in positive symptoms with antiulcer medication treatment.

•Antiulcer medication includes Cimetidine, Ranitidine, Omeprazole, Esomeprazole,

Lansoprazole, Pantoprazole, Rabeprazole, Dexrabeprazole. but prolonged exposure to
antiulcer medication has been associated with side effects including Weight changes, Nausea,
vomiting, mild diarrhea, Gas, Stomach pain Dizziness, Drowsiness, Tired feeling, Joint pain or
Sleep problems (insomnia)
 CONCLUSION

•From this study we can conclude that studies with plant sources can result in novel and
effective pattern of treatment. In this respect, traditional medicine has introduced good
protocols for treatment of various gastrointestinal disorders.

• Better activity of antiulcer has been clear that the medicinal plants play a vital role against
various diseases. Various herbal plants and plants extracts have significant antiulcer activity.

•Ayurveda, the oldest medicinal system in the world, provides leads to find therapeutically
useful compounds from plants. Therefore, ayurvedic knowledge supported by modern science
is necessary to isolate, characterize, and standardize the active constituents from herbal sources
for antiulcer activity.
Thank You