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Measles: Case Study: Hiro Landazuri Karla Gonzalez Jonathan Chen
Measles: Case Study: Hiro Landazuri Karla Gonzalez Jonathan Chen
Study
Hiro Landazuri
Karla Gonzalez
Jonathan Chen
Case
• Rubeola
• Paramyxovirus -
Morbillivirus
• Negative-sense
ssRNA
• F (fusion) protein/H
(hemoagglutanin)
protein
http://www.cdc.gov/vaccines/vpd-vac/measles/photos.htm
Overview
• Systemic infection
– Respiratory transmission
– Primary site of infection =
nasopharynx
• Primary viremia (2-3 days
post exposure)
• Secondary viremia (5-7 days
post exposure)
http://www.homehealth-uk.com/image_01/image/throatdiagram.gif
Physical Diagnosis
• The 3 C’s
– Cough, coryza,
conjunctivitis
• Koplik’s spots
• MV rash
– Maculopapular
• Macule – red lesion
flushing
• Papule – raised red lesion
dermatlas.med.jhmi.edu
Conjunctivitis
Koplik’s Spots
http://en.wikipedia.org/wiki/Conjunctivitis
MV rash
http://www.cdc.gov/vaccines/vpd-
vac/measles/photos.htm
Laboratory Diagnosis
• Isolation of MV from clinical specimen
• Serodiagnosis
– IgM ab (ELISA)
– IgG ab
• ELISA, HI, Indirect flourescent ab test,
microneutralization, plaque reduction
neutralization, complement fixation
Complement Fixation Assay
Positive Negative
http://web.indstate.edu/thcme/PSP/labtests/complementfix.htm
Treatment
• No treatment
• Supportive Care Only
– Tylenol, Non-steroidal anti-inflammatory drugs
like Advil, Aspirin, Motrin etc.
– Isolation
– Vitamin K
– Hydration
– Post-exposure Prophylaxis
• Antibiotics for serious complications (rare)
Melissa Burnett, MD, Measles, Rubeola, EMedicine from WebMD, http://www.emedicine.com/derm/topic259.htm (Oct. 29, 2007).
When was this patient contagious?
Melissa Burnett, MD, Measles, Rubeola, EMedicine from WebMD, http://www.emedicine.com/derm/topic259.htm (Oct. 29, 2007).
Why is this disease not common in the
United States?