Neurological complications of

SARS-COVID

Vorokhta Yurii. MD, PhD

 Incidence & Prevalence
͌36.9% of patients have neurological
manifestations, including:

62% - cerebrovascular event, (74% - ischemic

stroke, 12% - ICH, 1% - CNS vasculitis)

1% - Guillain‐Barre syndrome

31% - altered mental status (23% - due to

encephalopathy and 18% - due to encephalitis).
Quo Vadis?
The reported incidence of acute ischemic stroke in COVID-19
patients ranges from 2.5 to 5%. 
Wang Zilan, Yang Yanbo, Liang Xiaolong, Gao Bixi, Liu Meirong, Li Wen, Chen Zhouqing,
Wang Zhong COVID-19 Associated Ischemic Stroke and Hemorrhagic Stroke: Incidence,
Potential Pathological Mechanism, and Management . Frontiers in Neurology . 2020.
Vol.11 P. 1152 URL=https://www.frontiersin.org/article/10.3389/fneur.2020.571996
DOI=10.3389/fneur.2020.571996
“5.7% of patients with a severe course of coronavirus infection may
develop stroke”
“incidence of stroke in COVID-19 patients is about 5% with
an average age of 71.6 years”
Does COVID‐19 contribute to development of
neurological disease?

Immunity, Inflammation and Disease, First published: 17 December 2020, DOI: (10.1002/iid3.387)
 Fig. 1

Journal of Stroke and Cerebrovascular Diseases 2020 29DOI: (10.1016/j.jstrokecerebrovasdis.2020.105225)

Requena M et al., 2020
Stroke
ADEM
Acute encephalopathy
 The aim

to assess the stroke incidence in Odessa in the

context of the COVID epidemic.
 Material and methods
The analysis of reports on hospitalization of
patients with stroke for 2019-2020 was carried
out.
We studied the incidence of strokes in patients
under 50 years of age, as well as the incidence
of stroke detection in patients with
manifestations of acute COVID infection, as well
as convalescents after COVID.
 Results
According to the Odessa Regional Laboratory Center of the
Ministry of Health of Ukraine, as of January 15, 2021, 77,753
cases of COVID-19 were registered in the Odessa region. Of these,
34,839 people are residents of Odessa. It was found that,
compared to 2019, the number of hospitalizations has changed
slightly - from 933 to 976 hospitalizations per year ( = + 4.4%),
which corresponds to 93.3 and 97.6 cases per 100,000
population. The number of stroke patients under the age of 50
did not exceed 10% of the total number of hospitalizations.
In 2020, 58 (5.9%) cases of stroke were registered in patients
with manifestations of acute COVID infection and 112 (11.5%)
cases of stroke in convalescents after COVID.
GBD 2016 Stroke Collaborators. Global, regional, and national burden of
stroke, 1990-2016: a systematic analysis for the Global Burden of Disease
Study 2016. Lancet Neurol. 2019 May;18(5):439-458. doi: 10.1016/S1474-
4422(19)30034-1. Epub 2019 Mar 11. PMID: 30871944; PMCID:
PMC6494974.
 Conclusion
1. The incidence of stroke in patients with manifestations of acute
COVID infection in Odessa was 5.9%

2. The incidence of stroke in convalescents after COVID was 11.5%.