Introduction to Biochemistry

The Biology of Molecules

Professor Dr. R. K. Mahanta, Department of Biochemistry, Jorhat Medical College

 Guidelines for Users
• The materials presented are neither text material nor notes for the students.
• They should not be treated as substitute for the text books on the subject and
topics.
• These are presented and released for the students only as post delivery reference
on the topics covered in the classes for the students.
• The optimum benefit and use will be archived only by the students who had
actually attended these classes covering the topics.
• Use of the material without attending the classes may confuse and mislead the
student.
• In case of arising confusion, go through the available test book or reference
material and try to overcome the confusion reasonably.
• In situations of persistent confusion and controversy, the student is advised to
contact the Professor and Head of the Department of Biochemistry, Jorhat
Medical College personally.
 Basically Biology

is

Study of Living Materials

 Biology of Molecules

is

Study of Living Molecules

Study of Living Molecule
is
Molecularbiology
 Biochemistry
is
Misnomer for Molecularbiology

Biochemistry Represents
only a fraction of
Molecularbiology
 We study
The total Biology of living Molecules
not the fraction of chemistry
involved in Living

Therefore we study
Molecularbiology not Biochemistry
 Biochemistry – Molecular biology
• The scientific discipline that study the
molecular behavior under interactive
universal physicochemical forces associated
with formation, maintenance and replication
of living systems and character of molecules
originating in living systems
 Definition components
• The scientific discipline that study the
molecular behavior
• Under interactive universal physicochemical
forces
• Associated with formation, maintenance and
replication of living systems
• And character of molecules originating in
living systems
We study Molecules
Associated
with life

But What is LIFE?

 Let us try to define
Life in the perspective
of
Molecularbiology
Life-Living system –Living process
Life is the cumulative chronological outcome of a
thermodynamically open isothermal, dynamic,
non equilibrating physicochemical system
characterized with capacity for precise self
assembly, self regulation and self replication with
maintenance of system enthalpy at the expense
of exponential increase in extra system entropy
modulated by information molecules for system
regulation and transmittable during system
replication and system recombination to increase
system durability
 Definition components
• Cumulative chronological outcome
• Thermodynamically open isothermal, dynamic, non
equilibrating physicochemical system
• Capacity for precise self assembly, self regulation and
self replication
• Maintenance of system enthalpy at the expense of
exponential increase in extra system entropy
• Modulated by information molecules for system
regulation
• Transmittable during system replication and system
recombination
• To increase system durability
 The living systems
• The demarcated volume of universe with
characters of life is designated as a living
system.

• The dynamic molecular bilayer that separates

the system from the environment is the
system membrane.
 The Living Process and State

• The events going on in a living system is the

living process.
 
• The dynamic non equilibrating stage of the
system is the living state.
 The Events and Participants
• The chemical changes and events in the living
system is metabolism.
 
• The molecules taking part in system
maintenance are the metabolites
Deviations, Remedies and Outcome

• Deviation of system status towards

equilibrium is disease.
•  Procedures taken to revert back system
deviations towards evolutionally accepted
status is treatment.
•  Irreversible system deviation producing
system equilibrium is death.
 Our Targeted Objective

• To procure adequate information over

principles and tools of Molecularbiology to
explore and exploit the fundamentals of Living
System and the Process for improvement of
quality in human health and society.
Thanks

It is a protein bubble