CNS Drugs

Drugs Acting on Central Nervous System

 Anxiolytic & Hypnotics*

•Benzodiazepines (Bromazepam)
•Barbiturates
What is Anxiety

Anxiety disorders are serious mental illness that involves

intense feelings of fear, tension, worry often associated
with specific situation, events or objects

Symptoms of anxiety

• Palpitation
• Tachycardia 
• Sweating 
• Tremor 
• Hypertension 
• Restlessness 
• Agitation
• GIT disorders
• Sleep disturbance.
For the relief of anxiety effectively

Orion offers
Product Information

Generic name : Bromazepam BP

Therapeutic group : Anxiolytic

Brand name : BROMAZEP

Justification of Brand Name : Bromazepam

Dosage Form : Tablet

Pack Size : 5x10’s

Strength : 3 mg

MRP/Box : Tk. 150/-

(Per Tk.3.00/Tab)
Drug Profile

 Bromazepam is a benzodiazepine with

general properties similar to those of
diazepam. It has been used in the short-
term treatment of anxiety disorders
occurring alone or associated with
insomnia.
 A white or yellowish crystalline powder.
Practically insoluble in water; sparingly
soluble in alcohol and in dichloromethane.
Protect from light.
 STRUCTURE OF BROMAZEPAM

Chemical name: 7-Bromo-1,3-dihydro-5-(2-pyridyl)-1,4-benzodiazepin-2-one

 BROMAZEP

Binds to specific site (GABA receptor/Chloride channel complex)

Facilitates the action of GABA

Greater entry of Chloride ion

Chloride ion hyperpolarizes the cell

Reduction the neural excitability

Reduction of Anxiety
 Mechanism of action

Bromazep facilitates the action of

GABA & thereby reduces anxiety and
induces sleepiness
 Indications

• Anxiety & tension states (Short term use)

• Anxiety associated psychological problems

• Anxiety associated hypertension

 Dosage Guideline

Usual adult dose: 1.5-3.0 mg up to 2/3 times

daily

Maximum Dose : 60 mg daily

Product positioning
Be fresh, Be healthy
Contraindication

• Respiratory depression

• Acute pulmonary insufficiency

• Sleep apnoea

• Severe hepatic impairment and

• Myasthenia gravis
Side effects

•Drowsiness
•Lightheadedness
•Confusion and ataxia (especially in the elderly)
•Amnesia,
•Dependence,
•Muscle weakness
•Headache,
•Vertigo,
•Hypotension,
•Salivation changes,
•Visual disturbances
•Tremor
•Changes in libido
 Unique Selling Proposition (USP)

• Shows outstanding anxiolytic effect with well

tolerability

• Exhibits effective control of anxiety associated

hypertension

• More effective than Diazepam in anxiety Neurosis

• More effective than Lorazepam

 Competitors

Xionil--- Novartis
Tenil-- Acme
Bopam- Opsonin
Lexotanil- Healthcare
Laxyl Square
Norry Renata
Bromazep Orion
Target doctors

• Cardiologists
• Medicine Specialists
• Potential GPs
• Psychiatrists
• Internee Doctors