Interstitial nephritis

dhr Putra Hendra SpPD

UNIBA

Dr S Chakradhar 1
Interstitial Nephritis / Tubulointerstitial nephritis

 Berbagai kelainan klinis yang sesuai dengan manifestasi

gangguan tubulus maupun interstitial
 Pada kasus berat dan lama dapat mengenai seluruh ginjal
yang mengakibatkan gangguan fungsi glomerulus bahkan
gagal ginjal.

Acute interstitial nephritis

 There is inflammation of interstitium and tubules.

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TUBULAR/INTERSTITIAL
DISEASES
 Acute Tubular Necrosis (ATN)
 Tubulointerstitial Nephritis
Causes :
Heterogenous group
 Any cause of acute interstitial nephritis if persists
 Glomerulonephritis,
 Autoimmune diseases,
 Toxin-Mushrooms, lead, merkuri
 Drugs-NSAIDs (rifampicin, penicilin)
 CIN (contrast induce nephropathy)
 Obstructive
 Congenital
 Metabolic
 Infection (pyelonephritis, tuberculosis)

Dr S Chakradhar 4
Dr S Chakradhar 5
Clinical features

 Patients may give history of drug hypersensitivity,

 Fever, Rash, Arthralgia ,
 Acute Renal Failure (non – oliguric)

Investigations

 TC, DC, ESR, Hb

 Urine RME – RBC, WBC, WBC cast, proteinuria & eosinophiluria
 Renal biopsy

Dr S Chakradhar 6
Management

 Menghentikan faktor presipitasi- Drug or

treatment of infection,
 Corticosteroid dapat mempercepat
penyembuhan minimize scarring
 Supporting treatment for ARF

Dr S Chakradhar 7
Chronic interstitial nephritis

 Dapat merupakan lanjutan acute disease

 Dapat tanpa gejala akut
 Berakibat interstitial fibrosis & tubular
atropy

Dr S Chakradhar 8