Chemical Mediators of Acute Inflammation - Presentation

You might also like

Download as pptx, pdf, or txt
Download as pptx, pdf, or txt
You are on page 1of 41

Chemical Mediators of Acute

Inflammation

Prepared by:
Rawa Muhsin
Types of Mediators

2
Types of Mediators

3
The Mediators
 Cell-Derived Mediators
 Vasoactive Amines: Histamine and Serotonin
 Cytokines: IL-1, TNF, and Chemokines
 Eicosanoids
 Reactive Oxygen Species
 Nitric Oxide
 Leukocytic Lysosomal Enzymes
 Neuropeptides and PAF

 Plasma Protein-Derived Mediators


 Complement System
 Coagulation and Kinin Systems

4
Histamine

5
Histamine

6
Serotonin

7
The Mediators
 Cell-Derived Mediators
 Vasoactive Amines: Histamine and Serotonin
 Cytokines: IL-1, TNF, and Chemokines
 Eicosanoids
 Reactive Oxygen Species
 Nitric Oxide
 Leukocytic Lysosomal Enzymes
 Neuropeptides and PAF

 Plasma Protein-Derived Mediators


 Complement System
 Coagulation and Kinin Systems

8
Cytokines

9
IL-1 and TNF

10
IL-1 and TNF

11
Chemokines

12
Chemokines

13
Chemokines

14
The Mediators
 Cell-Derived Mediators
 Vasoactive Amines: Histamine and Serotonin
 Cytokines: IL-1, TNF, and Chemokines
 Eicosanoids
 Reactive Oxygen Species
 Nitric Oxide
 Leukocytic Lysosomal Enzymes
 Neuropeptides and PAF

 Plasma Protein-Derived Mediators


 Complement System
 Coagulation and Kinin Systems

15
Eicosanoids

16
Eicosanoids

17
Eicosanoids

18
The Mediators
 Cell-Derived Mediators
 Vasoactive Amines: Histamine and Serotonin
 Cytokines: IL-1, TNF, and Chemokines
 Eicosanoids
 Reactive Oxygen Species
 Nitric Oxide
 Leukocytic Lysosomal Enzymes
 Neuropeptides and PAF

 Plasma Protein-Derived Mediators


 Complement System
 Coagulation and Kinin Systems

19
Reactive Oxygen Species

20
Reactive Oxygen Species

21
Reactive Oxygen Species

22
The Mediators
 Cell-Derived Mediators
 Vasoactive Amines: Histamine and Serotonin
 Cytokines: IL-1, TNF, and Chemokines
 Eicosanoids
 Reactive Oxygen Species
 Nitric Oxide
 Leukocytic Lysosomal Enzymes
 Neuropeptides and PAF

 Plasma Protein-Derived Mediators


 Complement System
 Coagulation and Kinin Systems

23
Nitric Oxide

24
Nitric Oxide

25
Nitric Oxide

26
The Mediators
 Cell-Derived Mediators
 Vasoactive Amines: Histamine and Serotonin
 Cytokines: IL-1, TNF, and Chemokines
 Eicosanoids
 Reactive Oxygen Species
 Nitric Oxide
 Leukocytic Lysosomal Enzymes
 Neuropeptides and PAF

 Plasma Protein-Derived Mediators


 Complement System
 Coagulation and Kinin Systems

27
Leukocytic Lysosomal Enzymes

28
Leukocytic Lysosomal Enzymes

29
Leukocytic Lysosomal Enzymes

30
The Mediators
 Cell-Derived Mediators
 Vasoactive Amines: Histamine and Serotonin
 Cytokines: IL-1, TNF, and Chemokines
 Eicosanoids
 Reactive Oxygen Species
 Nitric Oxide
 Leukocytic Lysosomal Enzymes
 Neuropeptides and PAF

 Plasma Protein-Derived Mediators


 Complement System
 Coagulation and Kinin Systems

31
Neuropeptides and PAF

32
The Mediators
 Cell-Derived Mediators
 Vasoactive Amines: Histamine and Serotonin
 Cytokines: IL-1, TNF, and Chemokines
 Eicosanoids
 Reactive Oxygen Species
 Nitric Oxide
 Leukocytic Lysosomal Enzymes
 Neuropeptides and PAF

 Plasma Protein-Derived Mediators


 Complement System
 Coagulation and Kinin Systems

33
Complement System

34
Complement System

35
Complement System

36
Complement System

37
The Mediators
 Cell-Derived Mediators
 Vasoactive Amines: Histamine and Serotonin
 Cytokines: IL-1, TNF, and Chemokines
 Eicosanoids
 Reactive Oxygen Species
 Nitric Oxide
 Leukocytic Lysosomal Enzymes
 Neuropeptides and PAF

 Plasma Protein-Derived Mediators


 Complement System
 Coagulation and Kinin Systems

38
Coagulation and Kinin Systems

39
Types of Mediators

40
Thank you for listening.

41

You might also like