NIACIN

NIACIN

Niacin or nicotinic acid is also know

as PELLAGRA PREVENTIVE (PP)
FACTOR of Goldberg
Co-enzymes of niacin( NAD+ and
NADP+) are synthesized by
TRYPTOPHAN.
 CHEMISTRY

 Niacin is a pyridine derivative and structurally pyridine 3-

carboxylic acid
 Dietary nicotinamide , niacin and tryptophan contribute to the
synthesis of the co-enzymes NAD+ and NADP+
 CHEMISTRY

Nicotinamide is deaminated to niacin then undergoes

a series of reactions to form NAD+ and NADP+
Tryptophan produces quinolinate which then
forms nicotinate mononucleotide then to NAD+
and NADP+
60 mg of tryptophan= 1 mg of niacin for the
synthesis of co-enzymes
Nicotinamide liberated on degradation of co-
enzymes is mostly excreted in urine in the form
of N-methylnicotinamide
 SOURCES

 RICH SOURCES-liver , yeast , whole grains , cereals , beans

and peanuts

 MODERATE SOURCES-milk , fish , eggs and veggies

 RDA

Niacin Equivalents (NE) is used to represent

its RDA
ADULT-15-20 mg
CHILDREN-10-15 mg
Dietary tryptophan cannot totally replace
niacin
During pregnancy and lactation niacin
requirement is increased.
 ABSORPTION AND TRANSPORT

 Ingested niacin is absorbed primarily in the

small intestine , but some amount is absorbed
in the stomach. Once absorbed,
physiologically needed amount is converted to
NAD
 In the Liver , niacin amide is converted to
NAD. When needed by the body is liver NAD is
hydrolysed to niacinamide and niacin and
transported to tissues to serve as enzyme co-
factor
Thank you