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Pleural Empyema Management
Pleural Empyema Management
Management
Benoit Guery
Maladies Infectieuses
Philippe Ramon
Service d’endoscopie Respiratoire
CHRU Lille
Empyema formation
Exudative stage
fibrinous material forms on both pleural surfaces.
As more fibrin is deposited
Fibrinopurulent stage
may last several weeks
pleural surfaces may be joined by fibrinous septae
which cause the fluid to become loculated
Organisational stage
Proliferation of fibroblasts on the pleural surfaces,
which form an inelastic covering preventing adequate
lung expansion (fibrothorax).
Goals of the treatment
Results
Mono or polymicrobial ( 4-30%)
Variations between series
Variations between underlying conditions
Wait et al, Chest 1997 Cheng et al, Chest 2005
Maskell et al, NEJM 2005
Bacteriological data.
Streptococcus pneumoniae: 15-20%
Increased resistance
Staphylococcus:15-30%
Streptococcus spp
Gram Negative: 20-50%
Klebsiella, Enterobacter, Pseudomonas,
Hemophilus, E.Coli
Anaerobes:
Fusobacterium, Bacteroides fragilis
Microbiological diagnosis techniques
3 methods
- Standard culture
- PCA: Pneumococcal
capsular antigen
- 16S rDNA PCR confirmed
by pneumolysin PCR
Nosocomial
Tazobactam or Imipenem
+/- Aminoglycoside or Quinolone
Not Pneumococcus directed molecules
Size: 20 à 24
Bedside
Pleural Lavage
Isotonic saline
+/- Noxyflex (noxytioline)
Modalités
3 way stopcock
Directly through the CT: 250 to 500 ml
Cautiously if suspicion of broncho-pleural fistula
Timing:
Immediately after CT placement+++
Once a day until the liquid is clear
NOXYFLEX (noxytioline)
Pleural lavage
clamp 4h ( Chest 1996)
Video-assisted thoracic surgery
Collection<10 cm: unusual
Visual control of the CT position
5 mm introducer, 4 mm optical
Collection>10 cm
10 mm introducer
Two or three ports are made in the chest
One port is utilised for the camera and the others for
grasping instruments
Free fluid is evacuated and loculations drained under
thoracoscopic visualisation.
Fibrinous adhesions are separated and the pleural debris
removed from the pleural lining using endoscopic grasping
forceps or by extensive irrigation and suction.
Following the procedure, one or two chest drains are then
placed in the portholes.
Local antibiotics
Usually Rifampin or Colimycin
Still debated
Do not replace systemic treatment
Physiotherapy
Key to a correct evolution
After CT removal
Often and for a long time…..
Decrease surgery
Decrease long term pain and functionnal
limitations
Therapeutic choices
Guidelines to predict which patients with non-
purulent parapneumonic effusions warrant
chest tube drainage
240 patients with PPE
85 uncomplicated PPE
67 complicated PPE
88 empyema
76 yo
March 96: Pneumonia
April 96 : Left lung effusion
No fever, CRP 29, fibrinogen 7g/l
Exsudate, LDH 7200, glucose 0,24g/l
cytology PMN, negative direct
examination
VATS (25/4/96):
loculated
Removed debris and liquid (600ml)
Posterior CT n°24
Pleural lavage (Noxyflex)
CT removal on 2/5/96
Indications
Thoracocentesis
Failure
VATS
Surgery
Failure Failure
VATS Surgery
Surgery