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H01043-Hoá Dươc 2-Lecture 4-Antiparkinsons Drugs
H01043-Hoá Dươc 2-Lecture 4-Antiparkinsons Drugs
H01043-Hoá Dươc 2-Lecture 4-Antiparkinsons Drugs
Antiparkinson’s drugs
Phuong-Thuy Thi PHAN, M.S.
Recommended Reading
1) Beale, J.M., Block, J.H. (2011). Wilson and Gisvold’s Textbook
of Organic Medicinal and Pharmaceutical Chemistry 12th
Lippincott Williams & Wilkins: Baltimore. edition,
dopaminergic signalingChapter
agents, p.p. 471-490. 13.
Central
2) Beale, J.M., Block, J.H. (2011). Wilson and Gisvold’s Textbook of
Organic Medicinal and Pharmaceutical Chemistry 12th edition,
Lippincott Williams & Wilkins: Baltimore. Chapter 17. Cholinergic
drugs and related agents, p.p. 558-606.
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Parkinson’s disease
• Progressive degeneration of nigrostriatal dopaminergic neurons with
a resultant loss of dopaminergic/ cholinergic balance
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Biosynthesis of dopamine
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Metabolism of dopamine
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Central dopadecarboxylase
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Chemical induction of Parkinson’s disease
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Central dopadecarboxylase
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Peripheral dopadecarboxylase
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COMT inhibitors
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MAO-B inhibitors
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MAO-B inhibitors
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MAO-B inhibitors
Radical scavenger
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MAO-B inhibitors
Metabolism
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Dopamine agonists
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Dopamine agonists
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Muscarinic antagonists
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Adenosine antagonists
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Diagnostic imaging agents