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    Key Messages: Crohn's Disease

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    PHOENIX LUNA
    1. Crohn's disease risk factors include smoking, hygiene exposures, appendectomy history, certain microorganisms, medications like NSAIDs, western diet patterns with more fast food and sugar and less fiber, and stress. 2. The disease results from an abnormal immune response to intestinal microbes in a genetically susceptible host. An impaired epithelial barrier and dysregulated immune response lead to chronic inflammation. 3. The diagnosis of Crohn's is clinical based on symptoms, endoscopy, and imaging. Red flags include weight loss, bloody diarrhea, iron deficiency, and nighttime awakenings. A biopsy showing non-caseating granulomas also supports a diagnosis of Crohn's.

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    Key Messages: Crohn's Disease

    Uploaded by

    PHOENIX LUNA
    10 views9 pages
    1. Crohn's disease risk factors include smoking, hygiene exposures, appendectomy history, certain microorganisms, medications like NSAIDs, western diet patterns with more fast food and sugar and less fiber, and stress. 2. The disease results from an abnormal immune response to intestinal microbes in a genetically susceptible host. An impaired epithelial barrier and dysregulated immune response lead to chronic inflammation. 3. The diagnosis of Crohn's is clinical based on symptoms, endoscopy, and imaging. Red flags include weight loss, bloody diarrhea, iron deficiency, and nighttime awakenings. A biopsy showing non-caseating granulomas also supports a diagnosis of Crohn's.

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    Crohn's Disease

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    1. Crohn's disease risk factors include smoking, hygiene exposures, appendectomy history, certain microorganisms, medications like NSAIDs, western diet patterns with more fast food and sugar and less fiber, and stress. 2. The disease results from an abnormal immune response to intestinal microbes in a genetically susceptible host. An impaired epithelial barrier and dysregulated immune response lead to chronic inflammation. 3. The diagnosis of Crohn's is clinical based on symptoms, endoscopy, and imaging. Red flags include weight loss, bloody diarrhea, iron deficiency, and nighttime awakenings. A biopsy showing non-caseating granulomas also supports a diagnosis of Crohn's.

    Copyright:

    © All Rights Reserved
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    10 views9 pages

    Key Messages: Crohn's Disease

    Uploaded by

    PHOENIX LUNA
    1. Crohn's disease risk factors include smoking, hygiene exposures, appendectomy history, certain microorganisms, medications like NSAIDs, western diet patterns with more fast food and sugar and less fiber, and stress. 2. The disease results from an abnormal immune response to intestinal microbes in a genetically susceptible host. An impaired epithelial barrier and dysregulated immune response lead to chronic inflammation. 3. The diagnosis of Crohn's is clinical based on symptoms, endoscopy, and imaging. Red flags include weight loss, bloody diarrhea, iron deficiency, and nighttime awakenings. A biopsy showing non-caseating granulomas also supports a diagnosis of Crohn's.

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    of 9

    Key Messages

    crohn’s disease
    Risk Factor Analysis
    Theory In this patient

    1. Smoking
    2. Hygiene hypothesis
    3. Appendectomy
    4. Microorganisms
    Pathogenic bacteria [89], such as Campylobacter,
    Salmonella, and other bacteria inthe intestine.
    5. Medication
    including non-steroidal anti-inflammatory drugs
    (NSAIDs), oral contraceptives, antibiotics and others
    6. Nutrition :
    Patients with western lifestyle, such
    as intake of more fast food, higher sugar diet,and
    lower fiber diet.
    7. Stress

    Yulan Ye et al. 2015. The Epidemiology and Risk Factors of Inflamatory Bowel
    Disease. Int J Clin Exp Med 2015;8(12):22529-22542
    Key Message Pathophysiology
    Key Message Pathophysiology

    Na li, Rui-Hua Shi. 2018. Updated Review on Immune Factors in Pathogenesis of Chron’s
    Disease. World Journal of Gastroenterology 2018 January 7; 24(1):15-22
    Key Message Diagnosis

    • The diagnosis of CD is a clinical one and can be quite difficult given that the
    presenting symptoms can be insidious and nonspecific
    • Red flag symptoms that require further evaluation include weight loss, bloody
    diarrhea, iron deficiency, and night-time awakenings.
    • Similarly, significant family history of IBD, unexplained elevations in the c-reactive
    protein level, sedimentation rates, or other acutephase reactants (eg, ferritin and
    platelets), or low B12 should prompt further investigationfor possible CD.
    • The diagnosis of CD is made on the basis of symptoms and endoscopic and
    radiologicfindings

    Joseph D. Feuerstein, MD. 2017.Crohn Disease: Epidemiology, Diagnosis, and Management.Mayo Clicic
    Procceding. VOLUME 92,ISSUE 7, P1088-1103
    Key Message Diagnosis

    On pathology, the classic finding of CD is a


    noncaseating granuloma

    Joseph D. Feuerstein, MD. 2017.Crohn Disease: Epidemiology, Diagnosis, and Management.Mayo Clicic
    Procceding. VOLUME 92,ISSUE 7, P1088-1103
    Key Message Therapy

    Joseph D. Feuerstein, MD. 2017.Crohn Disease: Epidemiology, Diagnosis, and Management.Mayo Clicic
    Procceding. VOLUME 92,ISSUE 7, P1088-1103
    Key Message Management

    Journal of the Canadian Association of Gastroenterology, 2019, Vol. 2, No. 3


    Key Message Management

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