THESIS PROTOCOL

SUBA ARUL DEVI (POST GRADUATE STUDENT, DEPARTMENT OF RADIODIAGNOSIS,

KASTURBA MEDICAL COLLEGE, MANGALORE)

UNDER THE GUIDANCE OF

DR. AJIT MAHALE, MD RADIODIAGNOSIS, PROFESSOR,DEPARTMENT OF

RADIODIAGNOSIS, KASTURBA MEDICAL COLLEGE, MANGALORE
 ARTIFICIAL INTELLIGENCE IN
COMPARISON TO RADIOLOGICAL
REPORTING IN THE DIAGNOSIS OF ACUTE
BRAIN INFARCT WITH MRI
 AIM
 

• To study feasibility to use Artificial intelligence in

detection of Acute Brain Infarct (MRI)
 OBJECTIVES
• To collect retrospective and prospective images of infarcts (MRI) with
reports.

• To standardize reporting language using standard terminology from

literature.

• To use algorithms available to assess artificial intelligence in detecting

acute brain infarct as compared to radiologist reports.
 SAMPLE SIZE
• z1-α/2= The Standard normal deviate

• z1-β/2= The Standard normal deviate

• C=0.5 * ln [(1+r)/ (1-r)]

• Correlation Coefficient = r

•r=0.66, c=0.5
•n=30 the minimum number samples required for the study which is sufficient for AI study.
• Total no of samples required for artificial neural network training – 1000.

• Normal image – 500;infarct image – 500.

• Method of collection :

• Image shows feature suggestive of acute stroke, then section which shows
exact location of lesion will be extracted and reports have been made using
a standardised terminology.
• Method of collection :

• MRI Image which shows exact location of lesion will be extracted

• Reports have been made using a standardised terminology.

• Excel sheet data is created – image number, image sequence, findings on

each sequence, labels and classes.
Total Sample

100 100 Normal Image

Infarct Image
Infarct Images

6%

Haemorhagic Infarct

Ischemic Infarct

94%
Ischemic Infarct
14%

8%

MCA
PCA
ACA
10% AICA

68%
Haemorhagic Infarct

17%
33%
MCA
PCA
17%
ACA
AICA

33%
ARTIFICIAL NEURAL NETWORK
ANALYSIS
Voxel wise Label

Training Images

Voxel wise future extraction

Trained Machine

New Image

Voxel wise Detection

Gant Chart
NUMBERED TASKS 2021 2021 2021 2021 2021 2022 2022 2022 2022 AUG
JAN MAR JUN SEPT DEC MAR JUN JULY

Initial Literature                  
Review
Project Rationale                  
                 
Identify Target Group
                 
Design Investigation
                 
Protocol Submission

Data Collection                  

Data Analysis                  

Preparation of research                  
Paper
Submission of research                  
paper
REFERENCE
• G.A.Donnan ,M.Fisher,M.Macleod and S.M.Davis, “Stroke”, Lancet:2008;371:1612-1623.
• World Health Organisation, International Task Force for prevention of Coronary Heart
Disease and Stroke, Ethiology and Epidemiology of Stroke, 1980; WHO; Geneva;
Switzerland.
• Benjamin EJ, Virani SS, Callaway CW, et al. Heart Disease and Stroke Statistic-2018
updatea report from American Heart Association. Circulation.2018; 137:e67-e492.
• Liang chen, Paul Bentley, Daniel Rueckert. Fully automatic acute Ischemic lesion
segmentation in DWI using convolutional neural networks. Neuro image: Clinical
2017:15:633-643
• Machine Learning Approach to identify Stroke within 4.5 hours. Stroke.2020;51(3):860-
866.
• Anne Nielson, Mikkel Bo Hansen, Anna Tietze and Kim Mouridsen. Prediction of tissue
outcome and Assessment of Treatment Effect in Acute Ischemic Stroke Using Deep
Learning. Stroke.2018;49:1394-1401

• Charoensuk.W, Covavisaruch.N, Lerdlum.S, Likitjaroen.Y.Acute Stroke brain infarct

segmentation in DWI images.2015;4:115-122

• Nidiyare Hevia, Oscar Yanez-Suarez, Veronica Medina, Charlotte Rosso. Robust Non
Parametric Segmentation of Infarct lesion from Diffusion – Weighted MR
Images.2007;2102 – 2105

• Matus Straka, Gregory W. Albers, Roland Bammer. Real time Diffusion- Perfusion
Mismatch Analysis in Acute Stroke. J Magn Reson Imaging.2010;32(5):1024-1037
THANK YOU