A vision about…

Temporal Change Analysis for

Characterisation of
Mass Lesions in Mammography
Sheila Timp, Celia Varela and Nico Karssemeijer

Diagnóstico Assistido por Computador

Faculdade de Engenharia da Universidade do Porto 1

SUMMARY

Problem Block
Mains
Description Diagram

Results and
Applications
Conclusions

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MAINS

Temporal
CAD
changes
Program
Analysis

Improvement of
breast masses
Characterization

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 Functioning Advantages
Problem Description Program

The Radiologist provides

 Completely
the coordinates of the automatic Method;
present lesion .

Classification  Recommended
Analysis Method for lesions
The program performs un
automatic localization detected in previous
Radiology
matching the previous and current
screening. screenings;

Determines a ”single view” Use of temporal

and temporal
Problems in the characteristics to estimate characteristics;
classification of the probability that the
benign or malignant lesion is malignant.
lesions

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 Block Diagram

PRE-PROCESSING
Dataset Organ
Pre- Enhancemen Lesion
Segmentatio
processing t Detection
n

DETECTON
Feature
Extraction

Classificatio
n

Evaluatio
n
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 DATASET
Consecutive Total Dataset
Mammogra MLO 720
ms (Medio
Lateral Temporal Dataset
Oblique) Single View Dataset
542 pares
CC
(Cranio 465 MLO 178 CC
Caudal)

Se for indicado pelo 77 CC

especialista.

Temporal Dataset

Subset with visible Subset with

priors normal priors
202 263

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 PRE-PROCESSING
Image Detection
Segmentation Algorithm

- Background tissue;
- Pectoral muscle; Estimates the

s ic
potential presence of

2C
ist
- Breast tissue.

ha
er
a tumor inside the

ct

rac
ra
breast area.

te
ha

ris
2C
Peripheral

tic
s
enhancement
Detection of spiculation
Focal mass detection
pattern or distortion

- Correction of tissue
thickness differences;
Mass
- Removal of sharp
transitions in grey
Neural network likelihood
levels. classifier
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 DETECTION
Determination of
the mathematical Segmentation Characteristics determined at the
mass center of the Algorithm lesion
lesions

Radiologist marks
the lesion Temporal CAD Single View CAD

- Spiculation features;
- Regional Registration;
- Border features;
- Temporal features:
- Location features;
1. Difference features;
2. Similarity features. - Morphological
features;
- Micro calcifications.

Figure 2- Shows a malignant mass. The mass is

not yet visible on the prior view. The registration
programe selects the most probable location on
the prior view.
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 CLASSIFICATION
Suport Vector
Machine
Fig 1
Radial Basis Kernel

Not Equal Priors Equal Priors

20-fold cross Test :

validation Probability
scheme Model

Single View
Classifier
Training Set

Temporal Test Set

Classifier

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EVALUATION
Receiver Operating Characterist (ROC)
methodology

CAD without Temporal

CAD Temporal Features
Features

Figure 4 – Case
based ROC curves
for the single view
(SV) feature
vector and the
temporal feature
vector I (T I).

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RESULTS – CONCLUSION
Comparison with Radiologists
• Radiologists:
• Without prior mamograms: Az=0.76
• With the prior mamograms: Az=0.80
• CAD programme:
• Without prior mamograms: Az=0.77
• With the prior mamograms: Az=0.81
The use of temporal
Comparison with another study in regional registration features is an
effective approach to
• In this study 79% of all lesions were linked correctly. improve the
• In other study this percentage was 82% characterization of
the masses.
The improvement obtained was statiscaly significant
• P=0,005

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A vision about…

Temporal Change Analysis for Characterisation of

Mass Lesions in Mammography
Sheila Timp, Celia Varela and Nico Karssemeijer

Obrigada pela atenção!

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