Maximum Parsimony

B. RAKESH
MSC BIOINFORMATICS
21MSLSBF17
PHYLOGENETIC TREE BUILDING METHODS

 Two main methods

 1.distance-based UPGMA

Maximum parsimony
 2.character-based

Maximum likelihood
CHARACTER-BASED METHODS
 Maximum Parsimony
 In the method of maximum parsimony, the minimizing of the total character
state changes takes place during the phylogenetic analysis.
 Phylogenetic is a branch of biology that deals with studying evolutionary
relationships.
 A phylogenetic tree shows the evolutionary relationships based on a
common ancestor. Thus, when drawing a phylogenetic tree using the concept
of maximum parsimony, the amount of parallel evolution is minimized.
 Therefore, maximum parsimony will generate the tree much quicker than
other methods
 Tree 1
A A G G T T C C A C A C
H C G O H C G O H C G O
A-C

G-A G C-T C C-A C

P(3) P(6) P(7)

TOTAL CHANGES=4
 TREE 2
A G A G T C T C A A C C
H G C O H G C O H G C O
A-G T-C

G-A C-T C-A

P(3) P(6) P(7)

TOTAL CHANGES=5
M. Michael Gromiha, Protein Bioinformatics: From Sequence to Function,
Academic Press, 2010
D.E. Krane and M.L. Raymer, Fundamental concepts of bioinformatics, Pearson
Education Inc. 2006

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