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  • Luminal Phase: Ang-1 Ang-2 Ang-2 Ang-2 Ang-2

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    Elena Conti
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    This diagram outlines the process of blood vessel stabilization. Ang-1 binds to Tie2 receptors on endothelial cells and activates survival pathways like PI3K, stabilizing cell-cell junctions and the blood vessel. Ang-1 also reduces inflammation. In contrast, high levels of Ang-2 inhibit these stabilizing effects of Ang-1 by competing for Tie2 binding.

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    Angiopoietine

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    Figure_ang

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    This diagram outlines the process of blood vessel stabilization. Ang-1 binds to Tie2 receptors on endothelial cells and activates survival pathways like PI3K, stabilizing cell-cell junctions and the blood vessel. Ang-1 also reduces inflammation. In contrast, high levels of Ang-2 inhibit these stabilizing effects of Ang-1 by competing for Tie2 binding.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    5 views2 pages

    Luminal Phase: Ang-1 Ang-2 Ang-2 Ang-2 Ang-2

    Uploaded by

    Elena Conti
    This diagram outlines the process of blood vessel stabilization. Ang-1 binds to Tie2 receptors on endothelial cells and activates survival pathways like PI3K, stabilizing cell-cell junctions and the blood vessel. Ang-1 also reduces inflammation. In contrast, high levels of Ang-2 inhibit these stabilizing effects of Ang-1 by competing for Tie2 binding.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    Download as pptx, pdf, or txt
    of 2

    Ang-2

    Ang-1
    Ang-2
    Ang-2
    Ang-2
    Tie2
    Luminal phase
    Endothelial cell Endothelial cell

    Rho- Ca++ Cell- Cell junction


    Kinase
    PI3K -> stabilized
    Survival NFKβ ->

    Ang-1
    Antiinflammation
    Ca++
    Blood vessel
    stablized

    Abluminal phase
    Pericyte
    Ang-2
    Ang-1
    Ang-2
    Ang-2 Ang-2
    Tie2
    Luminal phase
    Endothelial cell Endothelial cell
    Rho- Ca++ Cell- Cell junction
    Kinase
    PI3K -> stabilized
    Survival NFKβ ->

    Ang-1
    Antiinflammation
    Ca++
    Blood vessel
    stablized

    Abluminal phase
    Pericyte

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