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Kuliah Mhs FKG Dan Farmasi Pem - Fungsi Ginjal Blok 9
Kuliah Mhs FKG Dan Farmasi Pem - Fungsi Ginjal Blok 9
Monitor functional
damage
Help determine
etiology
Laboratory tests of renal function
urine protein
glomerular filtration urine glucose
rate (GFR) hematuria
plasma creatinine osmolality
plasma urea
urine volume
urine urea
minerals in urine
Tests of renal function
urine protein
glomerular filtration urine glucose
rate=GFR
hematuria
plasma creatinine= Pcr
osmolality
plasma urea-Purea
urine volume= V
urine urea- Uurea
cystatin C in plasma?
Tests of Glomerular Filtration
Rate
Urea
Creatinine
Creatinine Clearance
eGFR
Cystatin C
Glomerular Filtration Rate (GFR)
Volume of blood filtered across glomerulus
per unit time
Inulin
+ Filtered only
– Not made by body; must be injected
Creatinine
+ An endogenous product of muscle
metabolism; near-constant production
– Filtered, but a bit secreted
Urea
+ An endogenous product of protein intake
– Filtered and absorbed; synthesis varies with diet0
Urea
Used historically as marker of GFR
Freely filtered but both re-absorbed and
excreted into the urine
Re-absorption into blood increased with
volume depletion; therefore GFR
underestimated
Diet, drugs, disease all significantly effect
Urea production
Urea
Product of protein catabolism
Filtered
UCr = 72 mg/dl
SCr = 2.0 mg/dl
V = 2 liters
time = 24 hours
Effect of
Test Use GFR muscle
mass