Formulation ,Characterization and

Evaluation of Sustain Release Table Of

Selected Drug Candecartan

PRESENTED BY
Mr. Bikash sahu
M PHARM (PHARAMACEUTICS)
SPER,BERHAMPUR UNIVERSITY ,ODISHA

GUIDED BY
Mr. Chandan Nayak
 CONTENT
1.INTRODUCTION
2.LITREATURE REVIEW
3.AIM AND OBJECTIVES
4.PLAN OF WORK
5. DRUG PROFILE
6.EXPCIPIENT PROFILE
 1.INTRODUCTION

Sustained release dose forms are intended to discharge a medication at a foreordained

rate by keeping up a consistent medication level for a particular timeframe with side
effects. The fundamental method of reasoning of continued discharge sedate conveyance
framework upgrades the biopharmaceutical, pharmacokinetic and pharmacodynamics
properties of a medication so that its utility is augmented, symptoms are diminished and
fix/treatment of the disease is 1 accomplished Introduction of lattice tablet as sustained
release (SR) has offered another reprieve through for novel drug delivery system (NDDS) in
the field of pharmaceutical technology.1 It bars complex creation techniques, for example,
covering and pelletization amid assembling and medication discharge rate from the dose
structure is controlled for the most part by the sort and extent of polymer utilized in the
arrangements. Hydrophilic polymer lattice is broadly utilized for planning a SR dosage
forms.
 LITREATURE REVIEW
Swapnali et al., (2017)20The main objective of of present examination is to define and
describe mucoadhesive fluid suppositories by utilizing chitosan based microspheres which
indicates great mucoadhesive property. The chitosan based microspheres were set up by
single emulsification method utilizing glutaraldehyde as a crosslinking specialist. Also, by
utilizing this candesartan celixitil loaded chitosan microspheres, fluid suppositories were set
up by chilly readiness technique. The readied microspheres were assessed by molecule size
and shape, medicate capture effectiveness, mucoadhesive power, swelling record, SEM,
FTIR, DSC studies and medication discharge profile. These assessedmicrospheres
straightforwardly consolidated in to the poloxamer 407(18%) gel. The readied fluid
suppositories assessed by Gelation temperature, thickness, surface PH, spreadability,
mucoadhesive power, tranquilize discharge profile. Chitosan indicates great mucoadhesion
property in the rectum and because of this arrival of medication was impeded up to 12hr
and arranged fluid suppositories demonstrates great gelation temperature. Accordingly the
chitosan microspheres consolidated fluid suppositories are best option in contrast to other
ordinary fluidsuppositories.
Ravi kumar kota et al., (2017) 24 The aim of the present examination was
to get ready and assess the Valsartan gliding microspheres for gastro retentive
drug delivery system. Eudragit RS 30D, HPMC grades, Guar Gum Sodium alginate
and calcium chloride were utilized as polymers. Fourteen preparations were
readied utilizing Ionotropic gelation method. All the microspheres were assessed
for molecule measure, % yield, drug entrapment efficiency, %and release rate of
the drug. In vitro medication discharge investigation of upgraded plan indicated
97.34 after 12 h in a controlled way. The promoted item demonstrates the
medication arrival of 94.26 inside 1 h.
Medication and excipient similarity thinks about were completed by FT-IR and no
communications were watched. The SEM of microspheres demonstrates an
empty round structure with a harsh surface morphology. The medication arrival
of Valsartan upgraded definition F13 pursued zero request, Higuchi and
Korsmeyer Peppas energy showing dissemination controlled with non fickian
(peculiar) transport mechanism.
Shilpa et al., (2016)25Candesartan cilexetil is an poorly soluble
antihypertensive agent with low bioavailability. Ion gelation
procedure is used for conveyance of protein and peptide drug and
includes arrangement of nano particles by methods for
electrostatic connections between the emphatically charged
chitosan chains and polyanions utilized as cross linkers. The most
broadly utilized polyanion is the tripolyphosphate (TPP). As
chitosan is dissolvable in acidic pH and decrease in molecule
measure was required to improve solvency and disintegration of
candesartan cilexetil, particles of candesartan cilexetil were set up
by ionotropic gelation procedure and assessed for molecule
estimate , surface morphology and immersion dissolvability. The
procedure was observed to be compelling for candesartan cilexetil
with molecule measure in the scope of 324 nm with a smooth
surface. Rate capture proficiency was in the middle of45-54%.
Deepti et al., (2015) 19A large portion of the right now accessible
medications are having poor water dissolvability and experience the ill
effects of low oral bioavailability. One of the the most encouraging ways
to deal with convey such insoluble medications is by dissolving it in
lipids, fluids or semi-solids to define new items. Candesartan meets the
prerequisite of high intensity yet it is inadequately ingested when
regulated as tablets. In this way the pro drug Candesartan cilexitil is
created. Two piece hard gelatin fluid filling cases are a standout amongst
the most sensible methodologies while picking the best measurement
structure to convey these new fluid details. Fluid filled plans were set up
by utilizing distinctive cosolventsandsurfactants.TheplancontainingSLS-
2%,PVP-17.5%,PEG-15%,andPG-

53% displayed want dissolvability, rheological property and observed to

be steady in hard gelatin cases.
 AIM & OBJECTIVES
Aim:
The purpose of this study to prepare polymeric microsphere containing
Candesartan by using Ionotropic gelation technique. The biocompatible polymers
were use for the preparation of microsphere.
The resultant microspheres were characterized for their size, Morphology,
Encapsulation Efficiency, and drug release.
Objectives:
The Objective of the present investigation was to microencapsulate the
Candesartan tranquilize. It is utilized to treatment of (hypertension). Bringing down
hypertension counteracts strokes, heart assaults, and kidney issues.
To give supported discharge and limiting or wiping out nearby symptom by
maintaining a strategic distance from the medication discharge in the upper
gastrointestinaltrack.
Thus point of present investigation was getting ready continued discharge
microspheres by Ionotropic gelation strategy utilizing Sodium alginate and
Tragacanth aspolymers.
 PLAN OF WORK
STEP-1:
•Litreature survey
STEP-2:
API CHARECTERIZATION
• Physical appreance
• Solubility studies
• FTIR studies
STEP-3:
 FORMULATION DEVELOPMENT
• By using Ionotropic gelation technique
STEP-4:
 EVALUATION OF MICROSPHERES
• Particle size analysis
• Determination of drug entrapments efficiency , drug loading and yield
• In vitro dissolution analysis
• Characterisation of microspheres
 Scanning electron microscopy
STEP -5:
 To study invitro Dissolution profile
 Drug release kinetics\
STEP-6:
 To perform stability study of selected formulation
DRUG PROFILE