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Kuliah 5 Struktur Sel Dan Fungsi Biologis Pada Sistem Kekebalan
Kuliah 5 Struktur Sel Dan Fungsi Biologis Pada Sistem Kekebalan
1. Organs
2. Cells
3. Molecules
•Lymph nodes
•Spleen
•Peyer’s patches
•Appendix
•Lymphatic vessels
•Bone marrow
• T-lymphocytes
• B-Lymphocytes, plasma cells
• natural killer lymphocytes
•Monocytes, Macrophage
•Granulocytes
• neutrophils
• eosinophils
• basophils
2. Acquired (adaptive)
• Second line of response (if innate fails)
• relies on mechanisms that adapt after infection
• handled by T- and B- lymphocytes
• one cell determines one antigenic determinant
•IgM
• produced as a first response to many antigens
• levels remain high transiently
•IgG
• produced after IgM
• higher levels persist in small amounts throughout life
• produced in large amounts during secondary
response
• persistence of antigen sensitive ‘memory cells’
after primary response
Laboratory Training for Field Epidemiologists
E P I D E M I C A L E R T A N D R E S P O N S E
IgM – IgG sequential response
Anamnestic
response
Antibody titer
IgG
IgM
Time
First stimulus
Second stimulus
Neutropenia Phagocytosis
Monocytopenia Bacteria killing
Institut Pasteur