HEPATOCELLULAR

CARCINOMA
Rahela Šafarić, 4th year
2021/2022
HEPATOCELLULA
R CARCINOMA
( HCC)
primary malignancy of the liver

underlying chronic liver disease

and cirrhosis ( 75% )
third most common cause of
cancer-related death worldwide
Highest incidence : Southeast
Asia and Africa
in Europe and USA incicidence is
rising
Regional variations in the mortality rates of HCC categorized by age-adjusted mortality
rates. The rates are reported per 100,000 persons.
MACROSCOPIC PICTURES OF HEPATOCELLULAR
CARCINOMA
MICROSCOPIC PICTURES OF
HEPATOCELLULAR CARCINOMA

Microscopic picture of variant HCC,

Microscopic picture of HCC Microscopic picture of a healthy liver fibrolamellar carcinoma
 ETIOLOGIC
FACTORS FOR
HCC
PATHOGENESIS OF
HEPATOCELLULAR
CARCINOMA
SYMPTOMS OF
HCC
 TREATMENT FOR
HEPATOCELLULAR
CARCINOMA
 PREVENTION OF
HEPATOCELLULAR
CARCINOMA
• 1) REDUCING THE RISK OF CIRRHOSIS:
a) drinking alcohol in moderation

b) maintain healthy weight

• 2) GET VACCINATED AGAINST HEPATITIS B

• 3) REDUCING THE RISK OF GETTING

HEPATITIS C INFECTION
 QUIZ
• 1.where is the highest incidence of HCC ? A) Europe
B) Canada
C) Southeast Asia and Africa
D) Australia
• 2. Which etiological factor will cause most of the HCC ?
A) Alcohol
B) HBV
C) HCV
D) obesity
QUIZ
• 3. Which of the following symptoms is not a symptom of HCC?
A) Jaundice
B) Loss of hearing
C) Enlarged abdomen
D) Easy bruising or bleeding
• 4. How many HCC patients are suitable for liver transplantation? ( in percentage)
A) 25%
B) 75%
C) 5%
D) 0%
QUIZ
• 5. How can we prevent hepatocellular carcinoma?
A) by drinking alcohol
B) by eating fatty food
C) vaccination against hepatitis B
D) vaccination against hepatitis C
 LITERATURE
• https://emedicine.medscape.com/article/2006744-overview
• https://www.gastrojournal.org/article/S0016-5085(07)00799-8/fulltext
• https://www.journal-of-hepatology.eu/article/S0168-8278(19)30341-1/fulltext
• https://www.mayoclinic.org/diseases-conditions/liver-cancer/symptoms-cause
s/syc-20353659

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629261/
• Robbins, Basic pathology , 9th edition
• https://www.roche.com/research_and_development/what_we_are_working_
on/oncology/liver-cancer.htm

• https://www.webmd.com/cancer/hepatocellular-carcinoma