Impact of Omega-3 Intake

on Cardiac Metabolism &

Arrhythmogenesis
Britt Soyebo
Background –
Cardiac Health
• Cardiac arrythmia is an irregularity
in a heartbeat
• Associated with substantial
mortality /morbidity and
economic costs
• Physiological Pathway:
• Low Cardiac Metabolism

(Rennison, 2009)
Background –
Dietary Lipids
• Dietary Fatty Acids
• primary energy substrate in the
healthy heart
• Types of Fatty Acids
• Saturated
• Trans fat
• Monounsaturated
• Polyunsaturated (PUFA)
• Omega-3 PUFA
• EPA, DHA, and ALA
• Omega-6 PUFA
• (LA)

(Kromhout, 2011)
 AHA Recommendations
• The AHA recommends that all
adults eat fish (particularly fatty
fish) at least two times a week
• For patients with documented
CHD, the AHA recommends ≈1 g
of EPA and DHA (combined) per
day.
• An EPA+DHA supplement may be
useful in patients with
hypertriglyceridemia.
Limitations
• No evidence has been found
for the optimal dosage or
ratios of Omega-3 – Omega 6
• No evidence to decide
dietary intake or therapeutic
supplements are the best
source of omega-3 fatty acids
• Sparce Research
 
Refreences
Jiang, Y., Tan, H. C., Tam, W. W. S., Lim, T. W., & Wang, W. (2017, December 30). A meta-analysis on omega-3 supplements in preventing
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Julie H. Rennison and PhD David R. Van WagonerPhD, Rennison, J. H., Julie H. Rennison From the Department of Molecular Cardiology,
Wagoner, D. R. V., David R. Van Wagoner From the Department of Molecular Cardiology, & Correspondence to David R. Van Wagoner.
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December 1, 2021, from https://www.ahajournals.org/doi/10.1161/CIRCEP.109.880773. 
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Nutrition, Appel, L. J., Lawrence J. Appel From the Department of Nutrition, Nutrition, F. the D. of, & Correspondence to Dr Penny M. Kris-
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