Obat-Obatan Anestesi

Ghina Tsamara
I4061192063

Pembimbing:
dr.Zeldi Ichsan, Sp. An
Intravenous Anesthetics
 Barbiturates
● Barbiturat menekan sistem aktivasi retikuler di batang otak, yang mengontrol kesadaran.
● Mekanisme aksi Barbiturates adalah melalui pengikatan pada reseptor γ-aminobutyric
acid type A (GABA A).
● Barbiturat mempotensiasi aksi GABA dalam meningkatkan durasi pembukaan kanal
spesifik ion Cl-.

Morgan GE.Clinical Anesthesiology, 5th ed. New York: Mc Graw-Hill Companies, Inc; 2013
 Barbiturates
● Intravenous bolus induction doses of barbiturates cause a decrease in blood pressure and an increase in heart
rate.
● Barbiturates depress the medullary ventilatory center, decreasing the ventilatory response to hypercapnia and
hypoxia.

Morgan GE.Clinical Anesthesiology, 5th ed. New York: Mc Graw-Hill Companies, Inc; 2013
 Benzodiazepine
● Benzodiazepin mengikat set reseptor yang sama di sistem saraf pusat dengan barbiturat tetapi mengikat
ke tempat yang berbeda.
● Benzodiazepin berikatan dengan reseptor GABAA meningkatkan frekuensi pembukaan kanal Cl-
● Flumazenil adalah antagonis benzodiazepin.

Morgan GE.Clinical Anesthesiology, 5th ed. New York: Mc Graw-Hill Companies, Inc; 2013
Benzodiazepine

Morgan GE.Clinical Anesthesiology, 5th ed. New York: Mc Graw-Hill Companies, Inc; 2013
Ketamine

Morgan GE.Clinical Anesthesiology, 5th ed. New York: Mc Graw-Hill Companies, Inc; 2013
Morgan GE.Clinical Anesthesiology, 5th ed. New York: Mc Graw-Hill Companies, Inc; 2013
Morgan GE.Clinical Anesthesiology, 5th ed. New York: Mc Graw-Hill Companies, Inc; 2013
Etomidate

Morgan GE.Clinical Anesthesiology, 5th ed. New York: Mc Graw-Hill Companies, Inc; 2013
Morgan GE.Clinical Anesthesiology, 5th ed. New York: Mc Graw-Hill Companies, Inc; 2013
Propofol
Inhalation Anesthetics
Morgan GE.Clinical Anesthesiology, 5th ed. New York: Mc Graw-Hill Companies, Inc; 2013
Morgan GE.Clinical Anesthesiology, 5th ed. New York: Mc Graw-Hill Companies, Inc; 2013
MAC adalah konsentrasi alveolar yang mencegah pergerakan 50% pasien dengan stimulus standar,
seperti insisi. Merupakan salah satu alat ukur yang penting karena MAC merupakan cerminan tekanan
parisal gas anestesi di otak.
Morgan GE.Clinical Anesthesiology, 5th ed. New York: Mc Graw-Hill Companies, Inc; 2013
Morgan GE.Clinical Anesthesiology, 5th ed. New York: Mc Graw-Hill Companies, Inc; 2013
Local Anesthetics
Morgan GE.Clinical Anesthesiology, 5th ed. New York: Mc Graw-Hill Companies, Inc; 2013
Morgan GE.Clinical Anesthesiology, 5th ed. New York: Mc Graw-Hill Companies, Inc; 2013
Morgan GE.Clinical Anesthesiology, 5th ed. New York: Mc Graw-Hill Companies, Inc; 2013
Thank you