CORRELATION BETWEEN MATERNAL BODY

MASS INDEX AND NEONATAL BIRTH WEIGHT

WITH INSULIN LIKE GROWTH FACTOR-1 (IGF-1)
LEVELS OF BREAST MILK

Dian Maharani, Bayu K, Prasetya I, Anik Puryatni

Nutrition and Metabolic Diseases Division-

Paediatric Department, Medicine Faculty of Brawijaya University
Saiful Anwar General Hospital Malang, East Java, 65141, Indonesia

1
BACKGROUND
Breast milk contain bioactive substances that support immune
system maturity, organ system development, and normal flora
colonization in neonates

(Boyd et al., 2006;Sullivan et al., 2010; Walker 2010)

Breast milk had significant contribution in neonatal gastrointestinal

barrier trough the role of growth factors and cytokines.

(Hawkes et al., 1999)

BACKGROUND
• Protein composition, imunity factors, growth factors, and
cytokin on breast milk depend on multifactors such as:
• Maternal age
• Lactation phase
• Breast milk volume
• Smoking
• Maternal body mass index
• Maternal infection

(Lucas& Cole, 1990; Bishara et al., 2009; Bachour et al., 2012; Hassiotou et
al., 2013; Dizdar et al., 2014)
BACKGROUND

Insulin-like Growth Factor - 1

• single chain peptide
• potent stimulator of proliferative growth by mitotic induction
• Potent stimulator of hypertrophic growth by promoting
anabolic process such as glucose transport, amino acid uptake
and protein synthesis.

(Sara &Hall 1990)

BACKGROUND

Insulin-like Growth Factor - 1

• single chain peptide
• potent stimulator of proliferative growth by mitotic induction
• Potent stimulator of hypertrophic growth by promoting
anabolic process such as glucose transport, amino acid uptake
and protein synthesis.

(Sara &Hall 1990)

 …Background

Aim of this study

To determine correlation between maternal body mass index and

neonatal birth weight with IGF-1 levels of breast milk
METHODS

This study was designed as a descriptive cross sectional study

Twenty four pairs of mothers-neonates collected in November to

December 2017

Maternal nutritional status was obtained by measuring body mass

index

IGF-1 levels of breast milk was measured by ELISA method

Data was analyzed Pearson correlation with significant value p<0.05

Ethical Clearance
• All pair of mother-neonatus was explained about
study and signing the informed consent

• This study had been approved by Ethical Committee

of Medical Faculty of Medicine, Brawijaya
University
Inclusion Criteria
• Maternal-neonatal pair admitted in Saiful Anwar Hospital
Neonatology ward and fully fed with breast milk
• Sample of beast milk collected in third day after delivery
• The patient parents allowed her baby to included in the
study after being briefed (informed consent).
 Exclusion Criteria
• Multiple congenital anomaly or malformation of
gastrointestinal system
• Neonatal infection

Drop out criteria

Baby not fully fed with breast milk
 Results

RESULT
 Results

Sample characteristics Frequency Percentage

Maternal Age
 < 17 years old -
87.5
 17-35 years old 21 / 24
12.5
 >35 years old 3 / 24
Maternal Body Mass Index
 <18,5 -
50
 18,5-24,9 12 / 24
29
 25-29,9 7 / 24 21
 >30 5 / 24
Maternal Educational State
4 / 24 16.5
 Elementary School
21
 Junior High School 5 / 24
25
 Senior High School 6 / 24 37.5
 Diploma 9 / 24
Maternal ocupation
12 / 24 50
 Housewife
50
 Employee 12 / 24
Parity
4 / 24 16.5
 Primipara
83.5
 Multipara 20 / 24

Gestational Age (weeks) (median)(min – max) 33 (22 – 40)

Berat badan lahir (gram) (mean) 2078
IGF-1 levels of breast milk (ng/ml) (mean) 2.67
Results
• Results showed that there was significant correlation
between IGF-1 levels of breast milk with maternal
body mass index (r=0.593; p=0.003) and neonatal
birth weight (r=0.426; p=0.038)
DISCUSSION
 Maternal Body Mass Index

• Half of the mother • Overweight and obesity

categorized as increased risk of
overweight and obese. prematurity.

(McDonald et al., 2010).

• Median gestational age • There was no significant
in this study was 33 correlation between IGF-1
weeks. levels with prematurity.
• There was no correlation
between IGF-1 levels of
breast milk with
gestational age (r=0.029;
p=0.084)
(Cooley et al.,2010).
 IGF-1 Levels
• There was significant • There were no significant
correlation between IGF-1 correlation between IGF-1
levels of breast milk with levels of breast milk with
maternal body mass index
(r=0.593; p=0.003) maternal body mass
index.

(Rasmussen et al., 1994; Veldhuis &

Iranmanesh, 1996)
 IGF-1 Levels
• there was significant • There were no significant
correlation between IGF-1 correlation between IGF-1
levels of breast milk with levels of breast milk
neonatal birth weight
(r=0.426; p=0.038) neonatal birth weight and
maternal body mass index
(more than 30)

(Adriana et al.,2013)
Conclusion
• The IGF-1 levels of breastmilk are positively
correlate to maternal body mass index and
neonatal birth weight.
Thank you