Simulation of S.

cerevisiae growth
and division
David Camilo Durán-Chaparro, Ph.D. Candidate
Pedraza Lab Groupmeeting, July 26th, 2021

1
2
3
Jin, M. et al. 2019

4
 Division Strategies

Facchetti, G. et al. 2017 5

Growth of S. cerevisiae

𝑁 =1

𝑁 =2
𝑔0 𝑔1
𝑔2 𝑁 =4 6
Growth of S. cerevisiae
𝑠2
𝑠1 𝑠1 𝑠1

𝑡𝑑
𝑠𝑏 𝑠𝑑

7
Exponential Growth
5
𝑠𝑑 4.5
𝑠 𝑑 =𝑠𝑏 𝑒 𝜇 𝑡
4

3.5 𝑠 𝑑 = ⟨ 𝑠𝑑 ⟩ + 𝜀
3

𝜀 𝑁 (0 , 𝜎2)
size

2.5

( )
2

1 ⟨ 𝑠𝑑 ⟩+ 𝜀
𝑠𝑏
1.5
𝑡 𝑑 = 𝑙𝑛
1 𝜇 𝑠𝑏
0.5

0
0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6
time
8
Simulations – Mother Machine Mode

( 𝑡 +1 ) (𝑡 ) ( 0)
𝑠 𝑏 =𝑠 =𝑠
𝑏 𝑑

9
Simulations – Bulk Mode

{
(𝑡 )
( 𝑡 +1 ) 𝑠 𝑖𝑓 𝑝 <0.5
𝑠 𝑏 = 𝑑
(𝑡 )
𝑠 𝑖𝑓 𝑝 ≥ 0.5
𝑏

10
Simulations – Lineage Mode

( 𝑡 +1 ) (𝑡 )
𝑠 𝑏 =𝑠
𝑑

11
Thank you!

12
Simulation of S. cerevisiae growth
and division
David Camilo Durán-Chaparro, Ph.D. Candidate
Pedraza Lab Groupmeeting, July 26th, 2021

13
References
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