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  • Routes of Administration: Mrs Deepika Bhatia Assistant Professor Pharmacology I Sub Code - Ptt-254

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    The document discusses various routes of drug administration. It begins by defining routes of administration as the path by which a drug enters the body. It then describes local routes like topical and deeper tissue administration. Systemic routes include oral, sublingual, rectal, and parenteral routes like intravenous, intramuscular, subcutaneous. The appropriate route depends on drug properties, dosage form, site of action, patient factors. Local routes are convenient for localized drug action while systemic routes allow drugs to enter circulation for widespread effect. Parenteral routes bypass gastrointestinal absorption.

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    The document discusses various routes of drug administration. It begins by defining routes of administration as the path by which a drug enters the body. It then describes local routes like topical and deeper tissue administration. Systemic routes include oral, sublingual, rectal, and parenteral routes like intravenous, intramuscular, subcutaneous. The appropriate route depends on drug properties, dosage form, site of action, patient factors. Local routes are convenient for localized drug action while systemic routes allow drugs to enter circulation for widespread effect. Parenteral routes bypass gastrointestinal absorption.

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    2 views17 pages

    Routes of Administration: Mrs Deepika Bhatia Assistant Professor Pharmacology I Sub Code - Ptt-254

    Uploaded by

    kashishmaggu
    The document discusses various routes of drug administration. It begins by defining routes of administration as the path by which a drug enters the body. It then describes local routes like topical and deeper tissue administration. Systemic routes include oral, sublingual, rectal, and parenteral routes like intravenous, intramuscular, subcutaneous. The appropriate route depends on drug properties, dosage form, site of action, patient factors. Local routes are convenient for localized drug action while systemic routes allow drugs to enter circulation for widespread effect. Parenteral routes bypass gastrointestinal absorption.

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    of 17

    Routes of Administration

    Mrs Deepika Bhatia


    Assistant professor
    PHARMACOLOGY I
    SUB CODE -PTT-254
    LEARNING OUTCOMES
    • To learn various route of administration
    • Purpose of all these routes and benefits

    Harpreet Singh Chandigarh University


    Routes of Administration
    A route of administration in pharmacology and
    toxicology is the path by which a drug,
    fluid, poison, or other substance is taken
    into the body.
    Harpreet Singh Chandigarh University
    Appropriate administration route depends on:

    • the dosage form in which the drug is available


    • Properties of drug
    • Site of action
    • the patient’s age, dose required
    • the patient’s condition, e.g. level of
    consciousness, etc.
    Local routes
    • This refers to the external application of drug
    to the surface for localized action.
    • It is convenient and easy for patient

    Harpreet Singh Chandigarh University


    Local routes
    • Topical
    Apply on skin, nasal mucosa, eyes, ear canal, vagina in the form
    of lotion /cream / lotion
    Other form is inhalers
    • Deeper tissue
    By using of syringe and needle (i.e. intrartrial injecion,
    intrathecal injections)
    • Arterial supply
    used in angiography i.e anti cancer drugs

    Chandigarh University
    Systemic route
    • Oral
    Older and comman way,
    safe convinient,
    Cheaper
    Solid/semisolid/capsule/
    tabltes
    Disadvantages
    Action is slower
    Cause vomiting and nausea

    Chandigarh University
    Cutaneous
    highly lipid soluble, apply on skin , prolong action
    (E. g .transdermal patches)

    Chandigarh University
    • Sublingual

    Placed under tongue, crushed in the


    mouth Action rapid (e.g
    buperenorphine) only lipid soluble
    and non irritant drugs are used

    • Rectal

    For irritate drugs, unpleasunt drug


    Unconsious patient (e.g diazepam)
    used in enema for systemic effect

    Chandigarh University
    ENTERAL ROUTE
    Placement of drug directly into any part of the
    GIT is called an 'enteral' mode of
    administration

    Chandigarh University
    Parenteral route
    (beyond intestine)
    Injections, directly in blood
    Any route of administration other than the oral
    route
    Parenteral
    • Intradermal injections
    injection raised a bleb (e.g BCG vaccine, senstivity testing)
    • Subcutaneous
    Drug depisit in loose SC tissues and supply to blood, avoided in shoked
    patient
    1. Dermojet
    2. Pellet inplants
    3. Sialastic and biodegrable implants
    • Intramuscular
    In large skeletal muscle (i.e TRICEPS) less pain full, Self injection

    • Intravenous
    • in the veins and reached supeficial, injected as a bolus(LUMP) and infuse
    slowly over hours. And effectis immedieatly
    angles
    OUTCOMES
    • TO LEARN THE VARIOUS ROUTES AND
    BENEFITS
    • DIFFERENCE B/W VARIOUS ROUTES AND
    THEIR EFFECTS

    Chandigarh University
    FAQS
    • WHICH ROUTE IS BEST FOR CHILDREN
    • WHICH ROUTE IS BEST FOR OLDER PATIENTS
    • WHICH ROUTE IS EASY

    Chandigarh University
    Reference
    k.d tripathi, essentials of medical
    pharmacology, 6th,2007. Jaypee publishers

    Harpreet Singh Chandigarh University

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