Vaccines and Immunity

T cell subsets
CD4 Effector T cell subsets
 Th1 cells: Differentiation and function

IL-12 secretion
response to intracellular pathogens
Activated DC
IFN-g---STAT1
IL-12---STAT4 T-bet
 Th1 cells: Differentiation and function
Intracellular viruses:
Th1 provides additional help to CD8
CTLS to destroy the infected cells

Intracellular pathogens: Increased expression of CD40 and TNF

Mycobacteria, Salmonella receptors
Toxoplasma, Leishnmania Autocrine secretion of TNF-a
Fusion of phagosomes with lysosomes
Heighten the microbicidal function Microbicidal reactive oxygen and nitrogen
of the infected Macrophages species

Further up-regulation of B7 molecules

Icreased expression of MHC II moelcules

Further activation of resting T cells

Th1 cells: Differentiation and function
 Th1 cells: Differentiation and function

NK cell driven Antibody-dependent cell-mediated cytotoxicity