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Gastriccancer 170426015531
Gastriccancer 170426015531
DR.SUNIL KAMBLE
ASSISTANT PROFESSOR
DEPT.OF
GEN.SURGERY
MNR MEDICAL
COLLEGE,SANGAREDDY
Introduction
• Intestinal Type
Diffuse type
• Cell cohesion absent, with individual cells
infiltrating and thickening stomach wall
without forming a discrete mass.
• More often in younger age group.
• Develops throughout stomach, including
cardiac → loss of distensibility of gastric wall
(“linitis plastica” or "leather bottle"
appearance), with a far more ominous
prognosis.
• Above: low power view, with poorly
differentiated cancer arising from
mucosa and diffusely infiltrating all layers
of gastric wall
• Right: ↑ magnification, with effacement
of lamina propria of gastric mucosa
• Linitis plastica carcinoma diffusely infiltrates entire
gastric wall without forming an intraluminal
mass;wall typically thickened ~ 2-3 cm, with
leathery, inelastic consistency.
Intestinal Type
• Cohesive neoplastic cells forming gland - like
tubular structures
• Frequently ulcerative
• More commonly in antrum - prepylorus,
cardia - fundus and lesser curvature of
stomach, and often preceded by prolonged
pre - cancerous process
Bormann Classification
Polypoid
Ulcerating
Ulcerating / Infiltrating
Infiltrating
(Linnitus
Plastica)
Japanese Endoscopic Society (JES)
Classification
International Union Against
Cancer(UICC) staging of gastric cancer
Primary Tumour (T)
T1 – Tumor invades lamina propria/ submucosa
T1a- lamina propria
T1b-submucosa
T2 – Tumor invades muscularis propria
T3 – Tumor involves subserosa
T4a – Tumor perforates serosa
T4b – Tumor invades adjacent organs
Regional Lymph Nodes (N)
N0 : No lymph nodes
N1 : Metastasis in 1 - 2 regional nodes
N2 : Metastasis in 3 - 6 regional nodes
N3a : Metastasis in 7 - 15 regional nodes
N3b : Metastasis in more than 15
regional nodes
Distant Metastasis (M)
M0 : No distant metastasis
M1 : Distant metastasis (this includes peritoneum and
distant lymph nodes)
• A tumor may penetrate the muscularis propria
with extension into the gastrocolic or
gastrohepatic ligaments, or into the greater or
lesser omentum, without perforation of the
visceral peritoneum covering these structures.
IB T2 N0 M0
TI N1 M0
II A T3 N0 M0
T2 N1 M0
T1 N2 M0
II B T4a N0 M0
T3 N1 M0
T2 N2 M0
T1 N3 M0
III A T4a N1 M0
T3 N2 M0
T2 N3 M0
III B T4b N0 M0
T4b N1 M0
T4a N2 M0
T3 N3 M0
III C T4b N2 M0
T4b N3 M0
T4a N4 M0
IV ANY ANY M1
Residual tumour (R)
• Thus, once tumors penetrate into the submucosa, the risk for
nodal metastasis increases with tumor size.
Early Gastric Cancer – Treatement Options
• Gastrectomy
Endoscopic Mucosal Resection
• Candidates for EMR:
– Tumors that have extremely low metastatic
potential
– Differentiated, superficial type IIa (slightly elevated
lesions), ≤ 2 cm in diameter.
– Differentiated, superficial type IIc (slightly
depressed lesions), without ulcer formation, ≤ 1
cm in diameter.
– Located in an easily manipulated area.
• Tumors invading the submucosa are at increased risk
for metastasizing to lymph nodes and are not
usually considered candidates for EMR.
• En bloc resection rate is significantly lower with
conventional EMR for tumors ≥11 mm than for
tumors ≤10 mm
Endoscopic Submucosal Dissection
N1 – 3 to 6 N2 – 1, 2, 7, 8 & 11 N3 – 9, 10 & 12
• Endoscopic palliation
• Surgical resection
• Palliative chemotherapy
• Palliative radiotherapy
Endoscopic Palliation
• Mortality 1-2%
• Anastamotic leak, bleeding, ileus, transit failure,
cholecystitis, pancreatitis, pulmonary infections, and
thromboembolism.
• Late complications -dumping syndrome, vitamin B-12
deficiency, reflux esophagitis, osteoporosis.
References
• Textbook of Gastroenterology, Yamada,
5th edition
• Sleisenger and Fordtran’s Gastrointestinal
& Liver Diseases, 9th edition
• Principles and Practice of Oncology,
DeVita, 9th edition
• Mastery of Surgery, 6th edition
• Bailey and Love short practice of surgery-
26th edition
• Sabiston textbook of Surgery , 20th
edition
• Schwartz textbook of Principles of
Surgery, 10th edition
• Gray’s Anatomy, 40th edition
• Skandalakis Surgical Anatomy,
2004