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TISSUES

Laboratory Activity #4
Tissues

· Tissues
· Groups of cells with similar structure and
function
· Four primary types
· Epithelium
· Connective tissue
· Nervous tissue
· Muscle

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.41
Epithelial Tissues
· Found in different areas
· Body coverings
· Body linings
· Glandular tissue
· Functions
· Protect underlying structures
· Acting as a barrier
· Permitting the passage of substances
· Secreting substances
· Absorbing substances
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.42
Epithelium Characteristics
1. Mostly composed of cells
2. Covers body surfaces
• exterior surfaces
• The lining of digestive, urinary,
reproductive and respiratory tracts,
heart and blood vessels, and lining of
many body cavities
Epithelium Characteristics
3. Distinct cell surface
Free or apical surface – where cells are
exposed and not attached to other
cells
Lateral surface – where cells are
attached to other epithelial cells
Basal surface – attached to the
basement membrane
Basement membrane – a specialized
type of extracellular material secreted
by epithelial and connective tissue cells
Epithelium Characteristics

4. Cell and matrix connections


5. Nonvascular
6. Capable of regeneration
• Replace damaged cells with new epithelial cells
Classification of Epithelium

· Number of cell layers


· Simple – one layer
· Stratified – more than
one layer
· Pseudostratified
columnar epithelium
Figure 3.16a

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.44a
Classification of Epithelium

· Shape of cells
· Squamous – flattened
· Cuboidal – cube-shaped
· Columnar – column-like

Figure 3.16b

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.44b
Simple Epithelium
· Simple squamous epithelium
· Single layer of flat cells
· Diffusion, filtration, some secretion
and protection
· Linings of blood vessels and heart,
lymphatic vessels, alveoli of the
lungs, portions of kidney tubules,
lining of serous membranes of body
cavities
Figure 3.17a
Simple Epithelium

· Simple cuboidal epithelium


· Single layer of cube-like cells
· Common in glands and their
ducts
· Forms walls
of kidney tubules
· Covers the ovaries

Figure 3.17b

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.46
Simple Epithelium
Simple Columnar Epithelium
• Single layer of tall, narrow cells
• Some have cilia or microvilli
• Can be found in glands and
some ducts, bronchioles of the
lungs, auditory tubes, uterus,
uterine tubes, stomach,
intestines, gallbladder, bile
ducts, ventricles of the brain
Pseudostratified Columnar
 Single layer, but some cells
are shorter than others
 Often looks like a double
cell layer
 Lining of the nasal cavity,
nasal sinuses, auditory
tubes, pharynx, trachea
and bronchi of the lungs

Figure 3.17d

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.48
Stratified Epithelium
· Stratified squamous
· Cells at the free edge are
flattened
· Found as a protective
covering where friction is
common, A barrier against
infection, reduces loss of
water from the body
· Locations
· Skin, Mouth, Esophagus

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.49
Stratified Epithelium

· Stratified cuboidal
· Two layers of cuboidal cells

· Stratified columnar
· Surface cells are columnar, cells
underneath vary in size and shape

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.50
Stratified Epithelium
· Transitional epithelium
· Shape of cells depends
upon the amount of
stretching
· Lines organs of the urinary
system

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.51
Glandular Epithelium
· Gland – one or more cells that secretes a
particular product
· Two major gland types
· Endocrine gland
· Ductless
· Secretions are hormones
· Exocrine gland
· With ducts
· Lined with the epithelium
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.52
Exocrine glands
• Composed of either single cells or many cells (multicellular glands)
• Multicellular exocrine glands :
• Simple glands - single, nonbranched duct
• Compound glands – multiple branched duct

According to secretory regions:


• Tubular – shaped as tubules ; can be straight or coiled
• Acinar or Alveolar – shaped in saclike structures

According to secretion types or how products leave the cell:


• Merocrine Secretion – involves release of secretory products through exocytosis
• Apocrine Secretion - release of secretory products as pinched-off fragments of the
gland cells
• Holocrine Secretion - involves the shedding of entire cells
Nervous Tissue
· consists of neurons
and support cells
· Function is to send
impulses to other
areas of the body
· Neurons (nerve cells)
· Cell body
· Dendrites
· Axon
Connective Tissue

· Diverse primary tissue type that makes up


part of every organ in the body
· Differs from the other 3 tissue types:
it consists of cells separated from each
other by abundant extracellular matrix

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.53
Connective Tissue
· Functions
· Enclosing and separating other tissues
· Connecting tissues to one another
- E.g. Tendons, Ligaments
· Supporting and moving parts of the body
- E.g. Bones, Cartilage
· Storing compounds
- E.g. Adipose tissues, bones

Slide 3.53
Connective Tissue
· Functions
· Cushioning and insulating
- E.g. Adipose tissues
· Transporting
- E.g. Blood
· Protecting
- Blood and Lymph

Slide 3.53
Connective Tissue Characteristics

· Variations in blood supply


· Some tissue types are well vascularized
· Some have poor blood supply or are
avascular
· Extracellular matrix
· Non-living material that surrounds living
cells

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.54
Extracellular Matrix
· 3 major components :
protein fibers, ground substance, fluid

· Protein Fibers
· Help form most connective tissues
· Three types
· Collagen fibers
· Elastic fibers
· Reticular fibers

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.55
Ground substance of matrix
-consists of nonfibrous molecules

Proteoglycans – are large molecules that


consist of a protein core attached to many
long polysaccharides
Cells of Connective Tissues
• -blasts : create the matrix
(osteoblasts, fibroblasts, chrondoblasts)
• -cyte : maintains the matrix
(osteocytes, fibrocytes, chrondocytes)
• -clast : breaks it down for remodeling
(osteoclasts)
• Macrophages
• Mast cells
Classification of Connective Tissues
Connective Tissue Proper
Supporting
Connective Connective Tissue
tissue proper
Supporting connective tissue
Loose Fluid Connective Tissue
Fluid connective tissue
• Areolar Cartilage • Blood
• Adipose • Hyaline • Hemopoietic Tissue
• Reticular • Fibrocartilage
• Elastic
Dense: Bone
• • Spongy
Dense, regular collagenous
• • Compact
Dense, regular elastic
• Dense, irregular collagenous
• Dense, irregular elastic
Loose Connective Tissue
• consists of relatively few protein fibers that form a lacy
· Areolar connective tissue
network, with numerous spaces filled with ground
·substance
Primarilyand
consists
fluid of
collagen fibers and few
elastic fibers
· Loose packing material of
most organs and other
tissues
• Substance on which the
basement membranes of
epithelia often rest
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.60
Loose Connective Tissue
· Adipose tissue
· Many cells contain
large lipid deposits (adipocytes)
· Matrix is composed of large
cells with little amount of
extracellular fluid
· Functions
· Insulates the body
· Protects some organs
· Serves as a site of
energy storage Figure 3.18f

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.61
Loose Connective Tissue
· Reticular tissue
· Delicate network of
interwoven fibers
· Forms stroma (internal
supporting network) of
lymphoid organs
· Lymph nodes
· Spleen
· Bone marrow

Figure 3.18g

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.62
Dense Connective Tissue
· Dense connective tissue
2 major types:
· Collagenous
· Elastic
· Examples of dense collagenous
· Tendon – attach muscle to bone
Dense regular
· Ligaments – attach bone to bone collagenous
· Dermis – connective tissue of the skin Dense irregular
collagenous
· Examples of dense elastic
· Vocal cords
Dense regular elastic
· Elastic ligaments
· Walls of arteries Dense irregular elastic
Figure 3.18d

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.59
Supporting Connective Tissue
· Cartilage – composed of chrondocytes in lacunae
· Hyaline cartilage
· Most common cartilage
· Composed of:
· Abundant collagen
fibers
· Rubbery matrix
· Entire fetal skeleton is
hyaline cartilage

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.57
Supporting Connective Tissue
· Fibrocartilage
· more collagen
· found in intervertebral
disks and some joints

· Elastic cartilage
· Provides elasticity
· Found in the external ear,
epiglottis and auditory tube

Slide 3.58a
Supporting Connective Tissue
· Bone (osseous tissue)
· Composed of:
· Bone cells in lacunae
· Hard matrix of calcium salts
· Used to protect and support
the body
· 2 types: spongy bone
compact bone
Figure 3.18a

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.56
Fluid Connective Tissue
· Blood
· Fluid matrix
· Functions as the
transport vehicle for
materials
· Formed elements
(RBCs, WBCs, Platelets)

Figure 3.18h
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.63
Muscle Tissue
· Function is to contract or shorten to
produce movement
· Three types
· Skeletal muscle
· Cardiac muscle
· Smooth muscle

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.64
Muscle Tissue Types
· Skeletal muscle
· Can be controlled
voluntarily
· Cells attach to
connective tissue
· Cells are striated
· Cells are long and
cylindrical have more
than one nucleus

Figure 3.19b

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.65
Muscle Tissue Types
· Cardiac muscle
· Found only in the heart
· Function is to pump
blood (involuntary)
· Cells attached to other
cardiac muscle cells at
intercalated disks
· Cells are cylindrical and
striated
· One nucleus per cell
Figure 3.19c

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.66
Muscle Tissue Types
· Smooth muscle
· Surrounds hollow
organs
· Involuntary muscle
· Tapered at each end
· No visible striations
· One nucleus per cell

Figure 3.19a

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.67
Tissue Repair
· Regeneration
· Replacement of destroyed tissue by the same kind of cells
· Fibrosis
· the destroyed cells are replaced by different cell types,
which causes scar formation
Events in Tissue Repair
· Capillaries become very permeable
· Introduce clotting proteins
· Wall off injured area
· Formation of granulation tissue
· Regeneration of surface epithelium
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.69
Regeneration of Tissues
· Tissues that regenerate easily
· Epithelial tissue
· Fibrous connective tissue and bone
· Tissues that regenerate poorly
· Skeletal muscle
· Tissues that are replaced largely with scar
tissue
· Cardiac muscle
· Nervous tissue within the brain and spinal cord

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.71
Developmental Aspects of Tissue

· Epithelial tissue arises from all three


primary germ layers
· Muscle and connective tissue arise from
the mesoderm
· Nervous tissue arises from the
ectoderm
· With old age there is a decrease in
mass and viabililty in most tissues
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 3.72

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