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  • DNA Repair

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    Fingertip Guide
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    There are 4 main DNA repair systems: direct repair, mismatch repair, excision repair (which includes base excision repair and nucleotide excision repair), and recombinational repair. Excision repair involves excising the damaged polynucleotide and resynthesizing the DNA. Base excision repair is initiated by a glycosylase and involves cleaving the N-glycosidic bond to create an apurinic site. Mismatch repair involves 3 systems to repair long, short, and very short mismatched patches of DNA.

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    There are 4 main DNA repair systems: direct repair, mismatch repair, excision repair (which includes base excision repair and nucleotide excision repair), and recombinational repair. Excision repair involves excising the damaged polynucleotide and resynthesizing the DNA. Base excision repair is initiated by a glycosylase and involves cleaving the N-glycosidic bond to create an apurinic site. Mismatch repair involves 3 systems to repair long, short, and very short mismatched patches of DNA.

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    12 views8 pages

    DNA Repair

    Uploaded by

    Fingertip Guide
    There are 4 main DNA repair systems: direct repair, mismatch repair, excision repair (which includes base excision repair and nucleotide excision repair), and recombinational repair. Excision repair involves excising the damaged polynucleotide and resynthesizing the DNA. Base excision repair is initiated by a glycosylase and involves cleaving the N-glycosidic bond to create an apurinic site. Mismatch repair involves 3 systems to repair long, short, and very short mismatched patches of DNA.

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    of 8

    DNA REPAIR

    4 different repair systems


    • Direct
    • Mismatch
    • Excision
    • recombination
    Direct repair
    • Directly on damaged nucleotides
    • photolyases
    Exision repair
    • Exision of polynucleotide and resynthesis
    • Bease excion and nucleotide exsicion
    Base excision repair
    • Initiated by glycosylase
    • Cleave N-glycosidic bond
    • Apurinic site created
    • AP endonuclease
    • DNAPI,exonuclease,ligase
    Nucleotide exsion
    • Breaking of phosphodiester bond between two sides
    • Forms gap
    • Uvr exision repair in E coli
    • uvrA,B,C=ABC Exinuclease
    • A,B attach to damaged site
    • A recognize damage
    • Departure of A allows C to bind
    • uvrD helicase
    • DNAPI, Ligase
    Mismatch repair
    • 3 systems
    • Long,short,very short patches
    • Long short-MutH,L,S
    • H,S recognize
    • Helicase ii, exonucleasei
    Recombinational repair
    • Post replication repair

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