Plasma cells , Natural killer cells

Presented by: Iram anwar

Plasma cells
 Derive from terminally differentiated B
cells that both synthesize and secrete
immunoglobulin.
 They cease to use immunoglobulin as a
membrane receptor
 produce large quantities of
immunoglobulin during their short life
span of less than 30 days.
Figure:Plasma cells
 Characterized by basophilic cytoplasm.
Natural killer cells
 constitute 5%-10% of lymphocytes in human
peripheral blood.
 Reflect their ability to kill certain virally
infected cells and tumor cells.
 Develop and mature both in the bone marrow
 NK cells are characteristically large granular
lymphocytes that express neither TCRs nor
BCRs.
Conti….
 killer activation receptors (KARs)

 killer inhibition receptors (KIRs)

 Also, natural killer cells produce cytokines that regulate some of the functions of T
cells, B cells, and macrophages.

 Unlike conventional T cells, NKT cells respond to lipids, glycolipids, or

hydrophobic peptides presented by a specialized,

 Non classical MHC class I molecule

 CD1d, and secrete large amounts of cytokines, especially interleukin-4

Figure: Natural killer cells