Slim-Excess®

The face and body designer

 1 | Short reminder of Slim-Excess ®
concept and results obtained on
body slimming efficacy

2 | New concept – Face remodeling

3 | New results on face remodeling

effect

4 | Conclusion

5 | Summary file

BASF Personal Care

 1 | Short reminder of Slim-Excess ®
concept and results obtained on
body slimming efficacy

2 | New concept – Face remodeling

3 | New results on face remodeling

effect

4 | Conclusion

5 | Summary file

BASF Personal Care

Ingredient Presentation
Slim-Excess® : How does it work ?
Lipogenesis
SLIM-EXCESS®  fatty acid uptake
 lipid synthesis and triglyceride
storage
 glucose uptake

Spermine / Spermidine
Trapped polyamines Lipolysis

 cAMP signalling

Adipogenesis

 Preadipocyte differentiation

4 BASF Personal Care

Slim-Excess ®
The polyamine catcher

Slim-Excess™
Spermidine sulfo-carrabiose unit

Polyamines are
physically trapped
to be inactivated

Optimal trapping
Spermidine

Quick action
Slim-Excess™

RATIO 1/1 RATIO 3/1

5 BASF Personal Care

Slim-Excess ®
A proven body slimming efficacy
Greater decrease in volume of thighs Greater decrease of thigh circumference
than placebo than caffeine* alone

*Measurement intergroup
**Complet results in the full
Body presentation
Quick and visible efficacy in 4 weeks,
n B ody
synergy observed with caffeine** en tatio
6 BASF Personal Care Prés
Slim-Excess ®
A proven body slimming efficacy

Visible decrease of cellulite within 2 weeks

© BASF Beauty Care Solutions

© BASF Beauty Care Solutions

France SAS
France SAS

Visible efficacy on cellulite and

greater results than placebo

7 BASF Personal Care

 1 | Short reminder of Slim-Excess ®
concept and results obtained on
body slimming efficacy

2 | New concept – Face remodeling

3 | New results on face remodeling

effect

4 | Conclusion

5 | Summary file

BASF Personal Care

 Fat & Face

Do you know on your face in how many main pockets fat is distributed?

 & - two on the cheeks

 & - two under the jaw
- one under the chin.
When fats accumulate in these pockets, the face
appears too round and its profile becomes
1 2 heavier.
5 3 4

Overtime facial bones and muscle fibers,

that hold fat pockets at the right places,
lose volume.
Fat shifts downward  baggy chins and
jowls, double-chin.
V-shape 20 60
U-shape
9 BASF Personal Care
How to fight migration of fat pockets?

Maybe a little bit barbarian….

10 BASF Personal Care
Slim-Excess®
The face designer

Unveil a more feminine and younger face

U Face V Face

Slim-Excess™ turns “U” shape into “V” shape

for a more triangular & feminine lower face by: Helping to "clear" excess
fat from the face

Refining and defining facial

contours on cheeks, jawline and
chin Creating perfect V-shaped
contours from every facet

11 BASF Personal Care

 Some existing cosmetic products
HR Collagenist LPG Soin global Clarins Shaping
V-Lift After 8 weeks, double- affinant Facial Lift Lipo
chin volume is
reduced. Neck Favor the elimination of fat The only skin care which
sagging and lower from double-chin and the “clears” the skin of all that
facial part regains its lower part of the face for a creates heaviness in the
V-shape. thinner V-shaped face face
6 % Anti-ageing exclusive Escin, caffeine,
Peptides, derivatives
complexe LPG oat sugars, baccharin extract
ceramides, Lipo-reducer
3 % Adipoless™

SKII product, 2B alternative

serum
Yves Rocher Serum
resculptant V
Slimming and anti-
slackening to V-shape
the face
Actif d’Argousier

Aloe Barbadensis Leaf Juice, Ginkgo Extract,

Coix Seed Extract, Seaweed Extract, Witch
Hazel Extract
12 BASF Personal Care
Ingredient from competitors
OVALISS™ - SEDERMA ADIPOLESS™- SEPPIC
“Keep your chin up!” Slimming concept

“Visibly reduces the double chin and

•Claims: Slimming quinoa extract that limits the quantity of
reshapes the facial contours” adipocytes in order to maintain the figure.

•Claims: Complex of ingredients that burn fat and inhibit the •INCI name: Butylene Glycol & Chenopodium Quinoa Seed
formation of new fat cells, may improve your profile. Extract

•INCI name: Coco Glucoside (and) Caprylyl Glycol (and) Alcohol •DU= 1 to 3%
(and) Glaucine

Also used for

•DU= 2.5% face slimming
•Launch date= 2007
•Sales price= 89 €/kg
56 days
•CIF= 2.22 €/kg
Anti-angiogenesis: limits neovascularization; isolation of
adipocytes, which cannot differentiate themselves

•Topically applied, Ovaliss noticeably reduced chin fat by more  Inhibits the maturation of functional adipocytes
than 10% in 7 out of 25 women >> no significant results
 Anti-MMP-9 action; inhibits neovascularization and the
•Not part of the Sederma’s catalog anymore differentiation of pre-adipocytes

13 BASF Personal Care

 1 | Short reminder of Slim-Excess ®
concept and results obtained on
body slimming efficacy

2 | New concept – Face remodeling

3 | New results on face remodeling

effect

4 | Conclusion

5 | Summary file

BASF Personal Care

In vivo study design
Protocol

© BASF Beauty Care Solutions France SAS

* Same
concentration in
active matter as in
commercial product
Slim-Excess™
15 BASF Personal Care
Photographs analysis
Cheek/chin angle

Cheek/chin angle (degree) from the front photographs of the face

  Measurement of inflexion angle between the cheek and the chin.

An improvement is characterized by
an increase of the
All the results are expressed in percentage of modification versus D0.
cheek/chin angle

16 BASF Personal Care

Photographs analysis
Cheek/chin angle

Statistically significant
improvement of
cheek/chin angle

Slim-Excess®
significantly better than
the placebo after 8
weeks

Efficacy on the low-face ptosis after only 4 weeks

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Photographs analysis
Double chin area

Double chin measurement (mm²) from the profile photographs of the face
The area of the double chin is defined by:
 inflexion point between the chin and the double chin,
 inflexion point between the neck and the double chin,
 the profile of the double chin which will be modeled by a manual
capture and a polynomial interpolation.

All the results are expressed in percentage of modification versus D0.

An improvement is characterized by
a decrease of the double chin area

18 BASF Personal Care

Photographs analysis
Double chin area

Statistically significant
decrease of double chin
surface

Slim-Excess ® demonstrated
superior activity
comparatively to placebo
treatment.

Efficacy after 4 weeks

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Biomechanical properties evaluation
Tonoderm™ equipment

Principle: Contactless method

Application of the force (4g) between the times T0 and T1 Hold of the force between the time T1
and T2 Cut off the force at T2

Studied parameters:
Ratio Cr/Yf: express the elastic/viscous behavior
of the skin

A decrease of the ration Cr/Yf express an improvement of skin elasticity

and a reduction of skin viscous component of skin behavior.
 

20 BASF Personal Care

Biomechanical properties evaluation

Statistically Skin elasticity

significant
decrease of the Skin viscous
ratio Cr/Yf behaviour

Slim-Excess® demonstrated superior activity comparatively to placebo treatment

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Volunteer result examples

Slim-Excess ® 2%

Baseline 12 weeks Baseline 12 weeks

© BASF Beauty Care Solutions France SAS

© BASF Beauty Care Solutions France SAS

© BASF Beauty Care Solutions France SAS

© BASF Beauty Care Solutions France SAS

Cheek/chin angle -40% double chin
improved by +12,2% area
Clear visible results
22 BASF Personal Care
23
© BASF Beauty Care Solutions France SAS

© BASF Beauty Care Solutions France SAS

BASF Personal Care

Baseline

Cheek/chin angle
improved by +8,7%
© BASF Beauty Care Solutions France SAS
© BASF Beauty Care Solutions France SAS
12 weeks
Volunteer result examples

Slim-Excess ® 2%

Clear visible results

Baseline

© BASF Beauty Care Solutions France SAS

area
12 weeks

© BASF Beauty Care Solutions France SAS

-23% double chin
24
© BASF Beauty Care Solutions France SAS

© BASF Beauty Care Solutions France SAS

BASF Personal Care

Baseline

Cheek/chin angle
improved by +5%
© BASF
© BASF Beauty
Beauty Care
Care Solutions
Solutions France
France SASSAS
12 weeks
Volunteer result examples

Slim-Excess ® 2%

Clear visible results

Baseline

© BASF Beauty Care Solutions France SAS

area
12 weeks

© BASF Beauty Care Solutions France SAS

-12% double chin
 1 | Short reminder of Slim-Excess ®
concept and results obtained on
body slimming efficacy

2 | New concept – Face remodeling

3 | New results on face remodeling

effect

4 | Conclusion

5 | Summary file

BASF Personal Care

Conclusion

Slim -Excess® fulfills market requirements for a new

generation of highly effective active slimming
ingredient by:
Refining and redesigning the body

Redrawing the contours of the face with

significant results

Visible results in only 4 weeks

Slim-Excess ® your face and body designer

26 BASF Personal Care

 1 | Short reminder of Slim-Excess ®
concept and results obtained on
body slimming efficacy

2 | New concept – Face remodeling

3 | New results on face remodeling

effect

4 | Conclusion

5 | Summary file

BASF Personal Care

 Slim-Excess®

Description: Red seaweed hydrolyzate

Reference: A00073

Dose of use: 1–3%

Aspect: Clear to opalescent pale yellow liquid

Solubility: Water-soluble

INCI Water, Butylene Glycol, Pentylene Glycol, Sodium

Chloride, Hydrolyzed Rhodophycea Extract

Regulations PCPC INCI 2007 INCI 2010 Not IECIC IECIC IECSC QD
Listed 2014 2012 2012 additive
Jap.
Pharma.

       x x x

28 BASF Personal Care

Slim-Excess® - Formulations

Slim-Excess®

W/Silicone
emulsion with 3%
W/O cream Slim-Excess®
formulation with 3%
Slim-Excess®

29 BASF Personal Care

Slim-Excess®
The face & body designer
- New concept: sulfo-carabioses molecular trap

- Proven efficacy on both the face and the body

- 3 combined slimming action inhibition of lipogenesis, actiation of

lyposis, inhibition of preadipocytes proliferation

- Visible and measurable reshaping effect on the face oval in vivo in

4 weeks assessed on Asian volunteers by an instrument evaluation of
 the «chin/cheek» inflexion angle
 the double chin area
 the biomechanical properties of the skin (elasticity).

- Efficacy significantly better than placebo

30 BASF Personal Care
DISCLAIMER
This document, or any answers or information provided herein by BASF, does not constitute a legally binding
obligation of BASF. While the descriptions, designs, data and information contained herein are presented in good faith
and believed to be accurate, they are provided for your guidance only. Because many factors may affect processing or
application/use, we recommend that you make tests to determine the suitability of a product for your particular purpose
prior to use. It does not relieve our customers of the obligation to perform a full inspection of the products upon
delivery or any other obligation. The claims and supporting data provided in this publication have not been evaluated
for compliance with any jurisdiction’s regulatory requirements and the results reported may not be generally true under
other conditions or in other matrices. Users must evaluate what claims and information are appropriate and comply
with a jurisdiction’s regulatory requirements. NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED,
INCLUDING WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, ARE MADE
REGARDING PRODUCTS DESCRIBED OR DESIGNS, DATA OR INFORMATION SET FORTH, OR THAT THE
PRODUCTS, DESIGNS, DATA, OR INFORMATION MAY BE USED WITHOUT INFRINGING THE INTELLECTUAL
PROPERTY RIGHTS OF OTHERS. IN NO CASE SHALL THE DESCRIPTIONS, INFORMATION, DATA, OR
DESIGNS PROVIDED BE CONSIDERED A PART OF OUR TERM SAND CONDITIONS OF SALE.

31 BASF Personal Care