Malignant peripheral nerve sheath tumour

A Case Reports
Rico Ikhsani1 , Roni Eka Saputra2

1
General Surgery Resident Faculty of Medicine Andalas University – Dr. M. Djamil Hospital
2
Orthopedy and Traumatology Department Staff Faculty of Medicine Andalas University – Dr. M. Djamil Hospital

BACKGROUND CASE DESCRIPTION

Malignant peripheral nerve sheath tumor A 65-year-old male with symptomps low back pain
(MPNST) is a locally aggressive soft for 6 months. Pain was radiate from lumbar joint
tissue sarcoma. It is characterized by especially when walking or when bending down.
Physical examination on thoracolumbar region
differen-tiation of the nerve sheath and found limitation of joint motion. On a radiological
has a high tendency to metastasize. In imaging, MRI study have shown mass on lumbar
addition, MPNST often accompanies region. Patient were assessed to lumbal
adults with neurofibroma type 1 (NF1) stabilitation decompression following removal
and usually develops from benign tumor with anterior approach. Pathology anatomy
plexiform neurofibroma. examination showed a MPNST Low Grade with
S100 (+).

DOCUMENTATION

DISCUSSION CONCLUSION

MPNST is a malignancy that often presents with

neurofibroma type 1. Clinical manifestations in
MPNST are dependent on tumor location and
invasion or compression of the tumor mass to the Patients with neurofibroma type 1 who have a
nerve plexus will cause neurological symptoms. significantly enlarged mass that was
Histopatho-logic examination is required in the previously asymptomatic should be suspected
definitive diagnosis in addition to MRI and FDG-PET. of malignancy. In addition to mass
The definitive management of MPNST is by surgical enlargement, patients usually complain of
resection, where surgery aims to achieve negative paresthesias, pain, weakness, and local
surgical margins. The prognosis of MPNST is
influenced by several things such as the presence or
neurologic deficits.
absence of metastasis, tumor grade, size, location,
surgical margins, and the presence of NF1.